Rheum MRCP Flashcards
Type 2 Hypersensitivity - Examples
Antibody + Complement-mediated
Autoimmune HA
“Wrong blood” reaction
Goodpasture’s
Examples of Type 2 hypersensitivity..
Antibody-dependent Cell-mediated
Medication-induced HA/ thrombocytopenia/ neutropenia
Transplant rejection
Immune reaction to parasites/ tumours
Example of Type 2 hypersensitivity
(Target cell dysfunction)
Pernicious Anaemia
Examples of Type 3 hypersensitivity
(Immune-Complex mediated)
SLE
Post-streptococcal GN
EAA (acute phase)
Serum sickness
Examples of Type 4 hypersensitivity
(“Delayed” and T-cell mediated)
GVHD
MS
Guillain-Barre
Allergic contact dermatitis
Scabies
Examples of Type 5 hypersensitivity
(Surface reception binding)
Graves’ disease
Myasthenia Gravis
Antibodies in Graves’ disease
TSHr stimulating (90%)
anti-Thyroid Peroxidase (75%)
Antibodies in Myasthenia Gravis
anti-nicotinic ACHr
Ankylosing spondylitis A features
Apical fibrosis
Anterior uveitis
Aortic regurgitation
Achilles tendonitis
AV node block
Amyloidosis
Antiphospholipid syndrome clotting screen
Paradoxically prolonged APTT
Low platelets
Drugs which cause drug-induced lupus
-procainamide
-hydralazine
less common causes:
-isoniazid
-minocycline
-phenytoin
Diffuse cutaneous systemic sclerosis - antibodies
anti-scl-70
(+ ANA + RF)
Limited cutaneous systemic sclerosis - antibodies
anti-centromere
(+ ANA + RF)
Pseudogout - risk factors
-haemochromatosis
-hyperparathyroidism
-acromegaly
-low magnesium, low phosphate
-Wilson’s disease
Septic arthritis - Kocher criteria
Fever >38.5
Non-weight bearing
Raised ESR
Raised WCC
