COPD clinical features and management Flashcards
What is the definition of Chronic Pulmonary Obstructive Disease?
Lung disease characterised by chronic obstruction of the lung airflow that interferes with normal breathing and is not fully reversible.
Airflow limitation is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases
Describe prevalence and incidence of COPD
1.2 million living with diagnosis and 50% undiagnosed in the UK
Prevalence is increasing
Incidence is decreasing
More males than females but is plateauing
What are factors that can cause COPD?
Smoking
Biomass fuel cooking - areas of deprivation
Air pollution
Occupation
Increase in age and if female
What are modifiable factors that can cause COPD?
Smoking
Biomass fuel cooking
Air pollution
Occupation
What are some non-modifiable factors that can lead to COPD?
Increase risk as age increases
Increase risk in females
Lower socioeconomic status
Asthma
Chronic bronchitis
Childhood infection
Explain Alpha-1 Antitrypsin deficiency
Rare, inherited disease, presents with early onset COPD in under 45 year olds.
Alpha-1 antitrypsin (AAT) is a protease inhibitor made in liver - limits damage caused by activated neutrophils which release elastase in response to infection/
cigarette smoke
Basal predominance to emphysema, liver fibrosis and cirrhosis
What are the risks of smoking that are linked to respiratory disease?
Greater annual rate of decline in FEV1 and greater COPD mortality than non-smokers
More than 50% of smokers develop COPD
What does smoking during pregnancy cause?
May affect foetal lung growth - smaller lungs and affects priming of the immune system
What are the main symptoms of COPD?
Cough, Breathlessness, Sputum, Frequent chest infections and Wheezing
Other symptoms - weight loss, fatigue, swollen ankles, age, smokigh, onset
What examinational findings could be found in a patient with COPD?
Cyanosis, Raised JVP, Cachexia, Wheeze, Pursed lip breathing, Hyperinflated chest, Use of accessory muscles and Peripheral oedema
What is the process of diagnosing COPD?
No single diagnostic test
Symptoms, History and Spirometry
What is the criteria for diagnosing COPD?
Typical symptoms
Above 35 years
Presence of risk factor - smoking or occupational exposure
Absence of clinical features of asthma
Airflow obstruction confirmed by post-bronchodilator spirometry
How does spirometry help diagnose a patient with COPD?
It diagnoses airflow obstruction
FEV1/FVC is less 0.7 after bronchodilator - COPD
Explain the stages of COPD and the values of spirometry expected?
Mild - 80% FEV1/FVC so diagnosis of COPD off of symptoms
Moderate - 50-79%
Severe - 30-49%
Very severe - FEV1 less than 30% of predicted
End stage COPD - used in practice
How can a chest X-ray be useful in diagnosis?
Excludes other pathologies and screen for malignancy.
X-ray can show vascular hila, hyperinflation, bulla, small heart and flat diaphragm
What are the specialist features of COPD?
Onset in mid-life
Symptoms slowly progressive
History of tobacco smoking or exposure to other types of smoke
Explain some differences between COPD and asthma
Symptoms under age of 35 are rare in COPD but often in asthma
Chronic productive cough in COPD
Breathlessness is persistent and progressive in COPD and in asthma is variable
Asthma is common for night time waking and wheezing
Variability of symptoms is uncommon in COPD and common in asthma
What can a pulmonary function test show about lung volumes?
Can show emphysema
There would be an increase in residual volume so increase in total lung capacity
RV/TLC> 30%
