Diagnosis and Staging of Lung Cancer Flashcards

1
Q

What is the systematic review of chest x-ray?

A

Lines/metal work, heart, mediastinum, lungs (zones),, bones, diaphragm and soft tissues

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2
Q

What do we need to look for in the mediastinum?

A

Hilar vascular structures should be crisply defined
No widening of the mediastinum
Trachea should be central

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3
Q

How should you look at lungs on chest x-ray?

A

\compare upper, mid and lower zones
Look between the ribs for lung detail
Remember to look ‘behind’ the heart

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4
Q

What is the sign of right upper lobe collapse in chest x-ray?

A

Horizontal fissure is pulled up along with hila and hemi-diaphragm
There is also reduced volume on the right

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5
Q

Why should we be aware of lobar collapse in smokers?

A

Can fail to resolve in smoker of age of above 45

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6
Q

Where can abnormalities hide in chest x-rays?

A

Can hide in apices, behind the heart, hemidiaphragm and hila
Compare with previous films and always look in review areas

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7
Q

What are the review areas in CXR?

A

Hila, lung apices, behind the heart and behind the diaphragm

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8
Q

What is included in the clinical history of lung cancer/

A

Increasing shortness of breath in smoker, history of pulmonary fibrosis and recent haemoptysis

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9
Q

What does the CT evaluate?

A

Size, shape atelectasis, border, density, solid or not solid, dynamic contrast enhancement and growth

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10
Q

What is a pulmonary mass?

A

Is an opacity in the lung over 3cm with no mediastinal adenopathy or atelectasis

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11
Q

What does atelectasis mean?

A

Lung collapse

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12
Q

What is a pulmonary nodule?

A

Is an opacity in the lung up to 3cm with no mediastinal adenopathy or atelectasis

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13
Q

What can be a pulmonary mass or nodule?

A

Lung cancer, metastasis, benign lung neoplasm, infection bacterial, TB or fungal and vascular haematoma, AVM

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14
Q

What is a hamartoma?

A

Benign lung tumour
Can show signs of calcification

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15
Q

What is pulmonary AVM?

A

Abnormal connections between a pulmonary artery and a pulmonary vein
Can cause paradoxical emboli that can lead to strokes or TIAs (transient ischaemic attack)

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16
Q

What contributes to the staging of lung cancer?

A

Clinical history/examination
Performance status
Pulmonary function
TNM international system

17
Q

Explain TNM staging

A

T - size and position of tumour
N - whether cancer cells have spread to lymph nodes
M - metastases

18
Q

What investigations are used to determine T?

A

CT, PET-CT and bronchoscopy

19
Q

What investigations are used to determine N?

A

PET-CT, mediastinoscopy, CT and EBUS/EUS

20
Q

What investigations are used to determine M?

A

PET-CT, CT and bone scan

21
Q

Explain PET scan

A

Functional imaging, labelled glucose analogue used, 18F - FDG
FDG taken up by metabolically active cells
It is not specific to diagnosis of malignancy

22
Q

What does T0 mean?

A

No evidence of primary tumour

23
Q

What does Tis mean?

A

Carcinoma in situ

24
Q

What scan is good for showing structures involved for T staging?

A

PET-CT scan

25
Q

What does N0 mean?

A

No regional lymph node metastases

26
Q

Describe PET scan and N staging

A

PET uptake does not equate to a malignant environment
Reactive nodes can also be metabolically active - infection

27
Q

What metastases are common for lung cancer?

A

Cerebral, skeletal, adrenal and liver

28
Q

What does M0 and M1 mean?

A

M0 - no distant metastases
M1 - distant metastases

29
Q

What are the positives of using PET-CT in staging?

A

Whole body staging in single study excluding cerebral
Discloses metastases and other pathology
Excludes metastases where imaging is abnormal
Non-invasive

30
Q

What are the limitations of PET-CT?

A

Tests can have false negative or false positives
False positives can be infection or inflammation
False negative can be a malignancy with low metabolic rate

31
Q

What investigations are used for tissue diagnosis?

A

Bronchoscopy and EBUS
Percutaneous image guided biopsy, fluoroscopy/CT/US guided

32
Q

What investigation is used to sample mediastinal nodes?

A

Mediastinoscopy
Mediastinotomy for anterior mediastinal nodes