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FTM 1 > Drugs > Flashcards

Drugs Flashcards

1
Q

Taxol

Category and mechanism

A

Anti-cancer

Prevent microtubule assembly

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2
Q

Colchicine

Category and mechanism

A

Anti-gout, anticancer

  1. Prevent microtubule assembly (polymerization)
  2. Fight inflammation
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3
Q

Vinctristine/Vinblastine

Category and mechanism

A

Anti-cancer

Prevent microtubule assembly

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4
Q

Phalloidin

Category and mechanism

A

Toxin (death mushroom)

Disrupt actin (microfilaments) function (hyperpolymerization)->no cell movement

-inhibits RNA polymerase II, not absorbed by GI tract

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5
Q

Cytochalasin

Category and mechanism

A

Toxin (death mushroom)

Disrupt actin function (hyperpolymerization)->no cell movement

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6
Q

Ciprofloxacin

Category and mechanism

A

ABX (Respiratory infection)

Inhibit DNA gyrase

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7
Q

Novabiocin

Category and mechanism

A

ABX (staph, MRSA)

Inhibit DNA gyrase

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8
Q

Nalidixic Acid

Category and mechanism

A

ABX (resp, UTI)

Inhibit DNA gyrase

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9
Q

Azidothymidine (AZT)

Category and mechanism

A

Anti-viral

Disrupt DNA elongation–> base lacks an 3’ OH

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10
Q

Didanosine (ddl)

Category and mechanism

A

Anti-viral

A viral reverse transcriptase that uses host cellular kinase to initiate chain termination due to the lack of a 3’OH

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11
Q

Tenofovir

Category and mechanism

A

Anti-viral

Disrupt DNA elongation–> competes with w/ dATP

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12
Q

Acyclovir

Category and Mechanism

A

Anti-viral (herpes)

A viral reverse transcriptase that uses viral kinases to initiate chain termination due to the lack of a 3’ OH

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13
Q

Adenine Arabinoside (AraA)

Category and mechanism

A

3’ OH=stereo restraint–> chain termination

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14
Q

Cytosine Arabinoside (araC)

Category and Mechanism

A

Anti-cancer

Initiate steric hindrance via the OH at position 2, which prevents polymerases adding the next dNTP

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15
Q

Camptothecin

Category and mechanism

A

Anti-cancer

Binds and inhibits topoisomerase I

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16
Q

Etoposide

Category and mechanism

A

Anti-cancer

Inhibits topoisomerase II

17
Q

Actinomycin D

Category and mechanism

A

Anti-cancer

Inhibit RNA polymerase BOTH pro/eukarytoes

18
Q

Rifampin

Category and mechanism

A

ABX

Inhibit RNA polymerase–> inhibit initiation of transcription

19
Q

Alpha-Amantin (mushroom!)

Category and mechanism

A

Toxin

Inhibits RNA polymerase II–> heptatoxicity–>death

20
Q

Streptomycin

Category and mechanism

A

ABX

Blocks initiation: prevents assembly of ribosomes by binding to 30S

21
Q

Tetracycline

Category and mechanism

A

ABX

Blocks elongation:prevents aminoacyl-tRNA access to A site

22
Q

Erythromycin

Category and mechanism

A

ABX

Blocks elongation: blocks ribosome translocation by binding to 50S

23
Q

Chloramphenicol

Category and mechanism

A

ABX

Blocks elongation: prevents peptidyl transferase activity in prokaryotes

If you give too much it can stop translation in mitochondria and effect your patient monitor concentration

24
Q

Cycloheximide

Category and mechanism

A

ABX

Blocks elongation: prevents peptidyl transferase activity in eukaryotes

25
Q

Puromycin

Category and mechanism

A

ABX

Blocks elongation: premature termination in translation by bearing structural resemblance to aminoacyl-tRNA

26
Q

Diptheria Toxin

Category and mechanism

A

Toxin

Inactivates EF-2–>prevent translocation

27
Q

Mycophenolic Acid

Category and mechanism

A

Immunosuppressive

Inhibits conversion of IMP to GMP

28
Q

Sulfomide/sulfa drugs

Category and mechanism

A

ABX

Inhibit folate synthesis

29
Q

Trimethoprim

Category and mechanism

A

ABX

Inhibit BACTERIAL dihydrofolate

30
Q

Methotrexate

Category and mechanism

A

Inhibit EUKARYOTIC dihydrofolate reductase

31
Q

Hydroxyurea

Category and mechanism

A

Anti-cancer

Inhibits ribonucleotide reductase

32
Q

Allopurinol

Category and mechanism

A

Anti-gout

Inhibits xanthine oxidase

33
Q

5’ Fluorouracil

Category and mechanism

A

Anti-cancer

Inhibits thidiylate synthase

34
Q

Zidovudine

A

Anti-viral

A viral reverse transcriptase that uses host cellular kinase to initiate chain termination due to the lack of a 3’OH

FTM 1 (15 decks)

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