Biopsychology Flashcards

1
Q

Nervous System

  • What is the Nervous System?
  • What are the two main functions of the Nervous System?
  • What subsystems is the Nervous System divided into?
A
  • Specialised network of cells in the body, primary internal communication system
  • Based on electrical and chemical signals
  • Two Main functions
  • To collect, process respond to info in environment
  • To coordinate working of different organs and cells in the body
  • Two subsystems- Central Nervous System (CNS) and Peripheral Nervous System (PNS)
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2
Q

Central Nervous System

  • What is the Central Nervous System made up off?
  • What is the purpose of (1)?
  • Describe the cerebral cortex
  • What is the purpose of (2)?
A
  • Made up of Brain (1) and Spinal cord (2)
  • Brain, centre all conscious awareness, cerebral cortex outer layer of brain only found in mammals highly developed, distinguishes our higher mental functions from other animals, consists of left and right hemisphere
  • Spinal cord extension off brain, passes messages to from brain, connects nerves to PNS, responsible for reflex actions
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3
Q

Peripheral Nervous System

  • What is the purpose of the PNS?
  • What is the PNS further subdivided into?
  • What does (1) govern?
  • What are the two main divisions of (1)?
  • What is the difference between the two divisions?
  • What does (2) govern?
A
  • Transmits messages via neurons to and from the CNS
  • Subdivided into Autonomic Nervous System (ANS) and Somatic Nervous System (SNS)
  • ANS (1) governs vital functions in body (breathing, heart rate, stress responses etc)
  • Two main divisions, Sympathetic and Parasympathetic Nervous Systems
  • Sympathetic stimulates organs and tissues
  • Parasympathetic inhibits organs and tissues
  • SNS (2) governs muscle movement, receives info from sensory receptors
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4
Q

Endocrine system

  • What is the Endocrine System?
  • What is the purpose of the Endocrine System?
  • What do glands do?
  • How do hormones travel and get received?
A
  • Complex network of glands and organs
  • Aims to control vital functions in the body
  • Slower than NS but very widespread powerful effects
  • Glands produce/secrete hormones
  • Hormones travel in bloodstream to any cell that has a receptor for that particular hormone (Example- Thyroxine affects cells in heart)
  • Most effect cells in more than one body organ leading to diverse powerful responses
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5
Q

Glands and Hormones

  • TOP|HAT represents glands
  • What do each of these glands secrete?
A
  • Pituitary Gland (“Master Gland”) controls release of hormones from all other endocrine glands
  • Hypothalamus secretes dopamine
  • Adrenal Gland secretes cortisol and adrenaline
  • Thyroid Gland secretes thyroxine
  • Ovaries secretes oestrogen and progesterone
  • Testes secretes testosterone
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6
Q

Fight or Flight

  • Give an example off this and systems used
  • Explain stages of the response till it ends
A
  • Endocrine system and Autonomic Nervous System (ANS) can work in parallel
  • An example of this is during a stressful event
  • Stressor introduced, amygdala (area of brain) associate’s situation with emotional response
  • Amygdala sends signal to Hypothalamus
  • Hypothalamus activates Sympathetic Nervous System, used to send signal to adrenal medulla
  • ANS goes from resting state (Parasympathetic) to a physiologically aroused state (Sympathetic)
  • Adrenaline released from adrenal medulla (Part of adrenal gland near kidneys) into bloodstream
  • Physiological changes in body (Increased heart rate) creates physiological arousal for fight or flight response
  • When threat passes, parasympathetic branch of ANS reverses changes bringing body back to normal resting state
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7
Q

Evaluation for Fight or Flight response

  • FR|BB&A|MR
A
  • Not just fight or flight response (Gray 1988)
  • Beta bias and Androcentrism (Taylor et al)
  • Fight or Flight is a maladaptive response
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8
Q

Not just fight or flight response (Gray 1988)

A
  • In stressful situation, not limited to F or F, some psychologists suggest an initial “freeze” response
  • Gray (1988), suggested first response to danger is to avoid confrontation altogether, demonstrated by freeze response
  • During this response, animals and humans are hyper-vigilant whilst assessing situation to decide best course of action for particular threat
  • Suggests that the F or F response is not complete, does not tell us all the steps taken in a stressful situation
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9
Q

Beta bias and Androcentrism (Taylor et al)

A
  • Early research typically conducted on only men (androcentrism), generalised universally (including women)
  • F or F response typically M response to danger, more recent research suggests F adopt a “tend and befriend” response
  • Taylor et al (2000), women more likely to protect offspring (tend), form alliances with other women (befriend) rather than fighting or fleeing
  • Women’s response to stress is to produce more oxytocin (love hormone), this reduces F or F and enhances tend and befriend, it is an evolved response
  • Suggests that research did not take the differences between the two genders into account, beta bias, assumed they both responded in the same way to stress/danger
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10
Q

Fight or Flight is a maladaptive response

A
  • Maladaptive just means an adaptation that is more harmful than helpful
  • F or F may have been useful for our ancestors that had to face life-threating situations (predators), modern day life rarely requires such an intense bio response
  • Stressors of modern-day life activate this response, can have negative consequences to health
  • For example, individual daces a lot of stress, continually activates Sympathetic NS, increases their blood pressure, can cause damage to blood vessels, can obtain heart disease
  • Suggests that this response is maladaptive in the modern day, it does more harm (blood pressure) than good because we don’t really need it anymore, more often than not its activated when it is not needed
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11
Q

Neurons

  • What are neurons?
  • What does this provide to the NS?
A
  • Million’s neurons in brain, 80% located in Brain
  • Neurons are nerve cells process and transmit messages electrically and chemically through signals
  • Gives NS primary means of communication
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12
Q

Types of Neurons

  • What are the three types of neurons?
  • What do they do?
A
  • Three Types of Neurons- Motor, Sensory and Relay
  • Motor Neuron- Connects CNS to effectors (Muscles & Glands), short dendrites long axons
  • Sensory Neuron- Carries messages from PNS to CNS, Long dendrites short axons
  • Relay Neuron- Connect sensory to motor or other relay, short dendrites short axons
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13
Q

Structure of Neurons

  • Fill in image
  • Describe each part
A
  • Cell body contains nucleus (contains genetic material of cell)
  • Dendrites carry nerve impulses from neighbouring neuron towards cell body
  • Axon carries impulses away from cell body
  • Covered in myelin sheath which protects, speeds up transmission of impulse
  • Nodes of Ranvier are the segmented gaps between myelin sheath
  • Speed up transmission because impulse jumps across gaps along axon
  • Terminal buttons located end of axon communicate with next neuron in chain across synapse (Gap between neurons)
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14
Q

Location of Neurons

  • Where are each located?
A
  • Motor neurons in CNS may have long Axons that form part of PNS
  • Sensory Neurons in PNS in clusters (Ganglia)
  • Relay Neurons (97% all neurons) in Brain and visual system
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15
Q

Electrical Transmission (Firing of Neuron)

  • What does “Firing of Neuron” mean?
  • Describe the steps
  • What is action potential?
  • What does this do?
A
  • When neuron in resting state, inside of cell negatively charged
  • When activated, inside cell positively charged for split second
  • Causes an action potential (spike in electric charge) to occur
  • Action potential creates an electrical impulse, this travels down axon towards end of neuron
  • Firing refers to if the electrical impulse continues down next neuron when received
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16
Q

Chemical transmission

  • How do neurons communicate?
  • How are signals transmitted with neurons?
  • How are signals transmitted between neurons?
  • What happens when signal reaches the end of the neuron?
A
  • Neurons communicate within groups known as Neural networks
  • Signals within neurons transmitted electrically
  • Signals transmitted between neurons transmitted chemically across synapse
  • When electrical signal reaches end of neuron (presynaptic terminal) neurotransmitters released from synaptic vesicles (tiny sacs)
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17
Q

Neurotransmitters

  • Fill in the image
  • What are neurotransmitters?
  • How are they used to transfer signals between neurons?
  • Describe Synaptic Transmission
  • Where are neurotransmitters found?
A
  • They are chemicals that diffuse across synapse to next neuron
  • The following are the steps of Synaptic Transmission
  • Once synapse crossed Postsynaptic receptor sites (located on dendrites of next neuron) receives them
  • Postsynaptic receptor sites convert chemical message back into electrical impulse
  • Process of transmission begins again in this other neuron
  • Direction is one way
  • Neurotransmitters have been identified in Brain, Spinal Cord and some Glands
  • Molecular structure fits perfectly with postsynaptic receptor sites (Lock and Key)
  • Have specialist functions (Acetylcholine causes muscles to contract)
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18
Q

Excitation and inhibition

  • What is excitation?
  • What is inhibition?
  • How does this relate to the firing of neurons?
A
  • Neurotransmitters has either excitatory of inhibitory effect on neighbouring neuron
  • Serotonin inhibition in receiving neuron, neuron more negatively charged, less likely to fire
  • Adrenaline excitation of postsynaptic neuron, increases its positive charge, more likely to fire
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19
Q

Summation

  • What is this process determining?
  • Describe the process
  • When is the action potential of the postsynaptic neuron triggered?
A
  • Whether postsynaptic neuron fires (sends electrical impulse down neuron) decided by this process
  • Excitatory inhibitory influences summed; net effect calculated
  • Net effect excitatory more likely to fire (Inside of postsynaptic neuron momentarily becomes positive)
  • Net effect inhibitory less likely fire
  • Once electrical impulse created it travels down neuron
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20
Q

Lateralization VS Localisation

  • What is Lateralization?
  • What is Localisation?
A
  • Localization is the idea that different areas of the brain are responsible for certain actions and behaviours
  • Lateralization is the localization of a function on one side of the body
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21
Q

Localisation Vs Holistic Theory

  • What research argues for localisation?
  • What is the holistic theory of how the brain functions?
A
  • Broca and Wernicke argued for localisation of function (cortical specialisation)
  • Idea that different parts brain, different tasks involved different parts body
  • If area damaged function associated with area also affected
  • Before this scientists supported the holistic theory that all parts of the brain are involved in processing thoughts and actions
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22
Q

Hemispheres of the brain

  • What does the Left Hemisphere control?
  • What does the Right Hemisphere control?
  • What is the Left Hemisphere linked to?
  • What is the Right Hemisphere linked to?
A
  • Left side of body controlled by right hemisphere
  • Right side of body controlled by left hemisphere
  • Physical, psychological functions controlled by particular hemisphere (Lateralisation)
  • Language linked to left hemisphere
  • Image processing linked to right hemisphere
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23
Q

The Motor, Somatosensory, Visual and Auditory Centres

  • What are the four “lobes”?
  • What areas are located at these “lobes”?
  • What do these areas do?
A
  • Cortex subdivided into four centres (“Lobes”)
  • Frontal, Parietal, Occipital, Temporal Lobes
  • Lobe associated different functions
  • Back of Frontal Lobe- Motor area, controls movement in opposite side of body
  • Front of Parietal Lobe- Somatosensory area, where sensory info from skin represented
  • Occipital Lobe located back of brain, visual area (visual cortex), sends info from left visual field to right visual cortex vice versa
  • Temporal Lobe-Auditory area, analyses speech-based info
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24
Q

Language centres of brain

  • What is the area located in the left frontal lobe?
  • What is the area located in the left temporal lobe?
  • What are these areas responsible for?
  • What are the effects when these areas are damaged?
A
  • Language restricted to left side of the brain
  • Broca identified “Broca’s Area”, located left frontal lobe responsible for speech production
  • When damaged speech is slow, lacks fluency, difficult to come out
  • Wernicke identified “Wernicke’s Area”, located in left temporal lobe, responsible for language understanding
  • When damaged individual gets Wernicke Aphasia
  • Produce nonsense words, fluent speaking that’s meaningless
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25
Q

Evaluation for Localisation

A
  • Evidence from neurosurgery (Scientific Credibility)
  • Evidence from Brain Scans (Scientific Credibility)
  • Counterpoint (Distributed not localised)
  • Language localisation questioned
  • Case Study Evidence
  • Counterpoint (Generalisation)
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26
Q

Evidence from neurosurgery (Scientific Credibility)

A
  • Damage areas of brain linked to mental disorders
  • When specific area of brain targeted, procedure successful
  • Suggests behaviours associated with serious mental disorders may be localised
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27
Q

Evidence from Brain Scans (Scientific Credibility)

A
  • Evidence everyday brain functions are localised
  • During procedures, Wernicke’s area active when doing listening task (understand what they are being told)
  • Broca’s area active during reading task
  • Review of LTM revealed episodic semantic memories stored different parts of prefrontal cortex
  • Objective methods for brain activity provide scientific evidence brain functions localised
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28
Q

Counterpoint (Distributed not localised)

A
  • Some Psychologist removed areas of cortex (10% to 50%) in rats that were learning route of maze
  • Learning seemed to require every part of cortex rather than particular area
  • Higher cognitive process not localised, distributed (Holistic)
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29
Q

Language localisation questioned

A
  • Language may not be localised to just Broca’s and Wernicke’s Area
  • Advancement in brain imaging (fMRI) gives us more clarity
  • Language function distributed more holistically
  • Language streams identified across cortex
  • Language may be organised more holistically contradicts localisation theory
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30
Q

Case Study Evidence

A
  • Gage, had rod through most of his left frontal lobe
  • Went from calm and reserved too quick-tempered and rude
  • Suggests Frontal lobe responsible for regulating mood
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31
Q

Counterpoint (Generalisation)

A
  • Case Study difficult to become generalised
  • Subjective interpretation of researcher
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32
Q

Hemispheric Lateralisation

A

Definition- Idea hemispheres functionally different, certain mental processes behaviours controlled mainly by one hemisphere

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33
Q

Left and Right Hemispheres

  • Where are the language centres located?
  • What does the right hemisphere contribute?
  • Which functions are lateralized?
  • Which functions are not lateralized?
A
  • Language centres only in left hemisphere
  • Language therefore lateralized (One side/hemisphere of body)
  • Right hemisphere can produce basic words and phrases, contributes emotional context
  • Vision, Movement, Somatosensory not lateralized (On both sides/hemispheres of body)
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34
Q

Split Brain Research

  • What does this research show us?
  • What disorder is this linked to?
  • Which part is severed?
A
  • Corpus callosum severed, reduces epilepsy
  • Epilepsy electoral activity travels one hemisphere to other, to reduce this, connections cut
  • Brain “split” two halves, study shows us how hemispheres function without communicating with each other
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35
Q

Sperry’s Research

  • Procedure
  • Findings
  • Conclusions
A

System to study how separated hemispheres deal with speech and vision

Procedure
* 11 People who went through split brain surgery studied using special setup
* LVF had image or word projected (RH would process) vice versa

Findings
* Picture shown in RVF (Processed in LH) could describe what they saw
* Shown in LVF (Processed in RH) could not do this
* Instead, could select matching object or in close relation (Ashtray–>Cigarette) using left hand
* Could draw image with left hand when seen in LVF (Processed in RH)
* Emotional Reaction (Giggle) when shown picture in LVF (Processed in RH)
* However, reported not seeing anything, “Flash of light”, “Nothing”

Conclusions
* Certain functions lateralised
* Supports view LH verbal RH “silent” but emotional

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36
Q

Evaluation for Lateralization

A
  • Lateralisation in the connected brain
  • Left or Right Brained people notion incorrect
  • Lateralisation Vs Plasticity
  • Research Support (Recent split-brain research)
  • Generalisation Issues
  • Ethics
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37
Q

Lateralisation in the connected brain

  • Fink et al (1996)
A
  • Strength, two hemispheres process information differently
  • PET Scans used identify what part brain active when looking at picture of forest
  • Looking at whole picture RH more active
  • Focusing on finer detail (Individual tree) LH tended to dominate
  • Suggests as far as visual processing concerned hemispheric lateralisation is a feature of a connected and split brain
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38
Q

Left or Right Brained people notion incorrect

  • Nielsen et al (2013)
A
  • Limitation, LH analyser RH synthesiser may be wrong
  • Research suggests no dominant side which creates different personality
  • Analysed Brain scans 1000 people, 7-28 (Good sample size and age range)
  • Certain hemispheres were used for certain tasks (Evidence for Lateralisation)
  • No evidence for dominant side (Maths Brain, Artist Brain)
  • Suggest right left brained people is wrong
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39
Q

Lateralisation Vs Plasticity

  • Rogers et al (2004)
A
  • Lateralisation adaptive, two tasks performed simultaneously, greater efficiency
  • Lateralised chickens, find food, watch for predators, “normal” could not
  • Plasticity adaptive functions taken over non-specialised area opposite hemisphere
  • Lateralization first preference (worth having if you can) but ultimately plasticity is more important
  • This is the case because it deals with brain damage
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40
Q

Research Support (Recent split-brain research)

A
  • Split brain performs better than connected on certain tasks
  • Identify anomaly faster
  • In normal brain, LH better cognitive strategies watered down by inferior RH
  • Supports Sperry’s earlier findings, Left and right brain distinct
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41
Q

Generalisation Issues

A
  • Casual relationships hard to establish
  • Compared to neurotypical control group
  • Nobody in control group had epilepsy (Confounding variable)
  • Differences / Unique functions of cognitive abilities could be epilepsy not split brain
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42
Q

Ethics

A
  • Participants not purposefully harmed (Protection from Harm)
  • Procedures explained (Debrief)
  • Full consent obtained (Informed consent)
  • Trauma may mean individual not fully understand what they agreed to
  • Repeated testing long periods may be stressful overtime
43
Q

Brain plasticity

  • How does the brain change throughout life?
  • What happens to rarely used connections, what is this called?
  • What happens when you learn something?
A
  • Brain can change throughout life
  • During infancy, rapid growth in number synaptic connections occur (15,000 per neuron, 2-3 years of age)
  • Twice as many in adult brain
  • Synaptic pruning, rarely used connections deleted, frequently used connections strengthened
  • New neural connections formed in response to new demands of brain
44
Q

Research into plasticity

  • Maguire et al (2000)
  • Draganski et al (2006)
A
  • Maguire et al (2000)- London taxi drivers, found more volume grey matter posterior hippocampus than control group
  • This area associated with spatial and navigational skills
  • Learning experience altered structure of their brains
  • Longer taxi driver in job, more pronounced structural difference (Positive correlation)
  • Draganski et al (2006)- Image brains med students three months before after final exams
  • Learning indued changes occur in posterior hippocampus, parietal cortex potentially as result of learning
45
Q

Functional Recovery

A

Definition- The brains ability to redistribute or transfer functions usually performed by damaged area to undamaged areas

46
Q

After brain trauma

  • What happens in the brain?
  • What may an individual require after a certain point?
A
  • Following physical injury such as stroke, unaffected areas brain adapt, compensate for areas that are damaged
  • Functional recovery example of neural plasticity
  • Healthy brain areas take over functions of damaged, destroyed or missing areas
  • This process can occur quickly after trauma (spontaneous recovery), slow down after weeks or months
  • Individual may require rehab therapy to further recovery at this point
47
Q

During recovery

  • Processes brain does to recover
A
  • Brain can rewire, reorganise itself by forming new neural connections close to area of damage
  • Secondary neural pathways activated “unmasked”, to enable functioning to continue
  • Masking supported by structural changes
  • Axonal sprouting- growth new nerve endings, connect undamaged nerve cells, new neuronal pathways
  • Denervation super-sensitivity- Axons become aroused to higher level, compensate for lost ones, could have negative consequence, oversensitivity to messages e.g., pain
  • Recruitment homologous (similar) areas opposite side brain- Specific task still performed, similar opposite side area takes functions of damaged destroyed area
  • Functionality could shift back to left after recovery
48
Q

Evaluation for Plasticity / Functional Recovery

A
  • Negative plasticity
  • Age and plasticity
  • Seasonal brain changes
  • Real world application
  • Cognitive reserve
  • Very small samples (5 people in one study), very difficult to generalise
49
Q

Negative plasticity

A
  • Negative behavioural consequences
  • Evidence shown prolonged drug use leads to poorer cognitive functioning in later life, increased risk of dementia
  • Amputees develop phantom limb syndrome (continued sensations which are unpleasant and painful in missing limb)
  • Due to cortical reorganisation in somatosensory cortex, as a result of limb loss
  • Brain’s ability to adapt to damage not always beneficial
50
Q

Age and plasticity

A
  • May be lifelong ability, reduces with age still present
  • Ladina Bezzola et al (2012), 40 hours golf training produced changes in neural representations of ppts aged 40-60
  • fMRI used, increased motor cortex activity in novice golfers compared to control group
  • Suggest more efficient neural representations
  • Shows plasticity can continue throughout life span
51
Q

Seasonal brain changes

A
  • May be seasonal plasticity in brain, response to environmental changes
  • SCN (regulates sleep/wake cycle), evidence this shrinks during spring, expands during autumn
  • Most work done on animals, humans may be different
52
Q

Real world application

A
  • Contributed to neurorehabilitation
  • Understanding axonal growth encourages new therapies
  • Constraint induced movement therapy used with stroke patients, repeatedly practice using affected part of body while unaffected part is restrained
  • Shows its useful, helps medical professionals know when interventions need to be made
53
Q

Cognitive reserve

A
  • Level of education may influence recovery rates
  • Eric Schneider et al (2014), more time in education greater their chances of being disability free recovery (DFR)
  • 40% achieved DFR had 16+ years in education, 10% 12+ years
  • Suggests people insufficient DFR less likely to achieve full recovery
54
Q

Scanning and other techniques

A

Purpose to investigate localisation, determine which parts brain do what

55
Q

Functional magnetic resonance imaging (fMRI)

  • What it does
  • How it is used
  • What it is
A
  • Detects changes in blood oxygenation and flow
  • Occurs as result of brain activity in specific parts of brain
  • Brain area more active consumes more oxygen
  • Blood flow directed to active area (haemodynamic response)
  • Scan produces 3 dimensional images (activation maps)
  • Shows parts of brain involved mental processes
56
Q

Electroencephalogram (EEG)

  • What it is
  • What it does
  • How it is used
A
  • Measures electrical activity in brain
  • Contains all neural responses associated with specific sensory, cognitive and motor events
  • Does this through electrodes fixed on scalp (skull cap)
  • Recording represents brainwave patterns, overall account of brain activity
  • Used by clinicians as diagnostic tool
  • Unusual arrhythmic patterns may indicate neurological abnormalities
57
Q

Event related potentials (ERPs)

  • What it is
  • What it does
  • How it is used
A
  • Types of brainwaves triggered by particular events
  • Researchers isolate responses from EEG
  • Statistical averaging used to filter original EEG data
  • Leaves responses related to presentation of specific stimulus, performance of specific task
  • Cognitive neuroscientists link ERPs to cognitive processes (attention, perception)
58
Q

Post-mortem examinations

  • What it is
  • What it does
  • How it is used
A
  • Brains of dead analysed
  • Individuals that had rare disorders, experienced unusual deficits in cognitive processing or behaviour
  • Areas of damage examined
  • Attempt to establish cause of affliction
  • May compare with neurotypical brain, highlight extent of differences
59
Q

fMRI Strengths and Limitations

A

Strengths
* Safely provides a clear picture of brain activity
* Does not rely on radiation
* Virtually risk free if administered correctly
* Non-invasive, straightforward to use
* Images have high spatial resolution (detail by mm)
* Clear picture of how brain activity is localised

Limitations
* Expensive compared to others
* Poor temporal resolution
* Due to 5 second lag, image on screen, firing of neuronal activity
* May not truly represent moment to moment brain activity

60
Q

EEG Strengths and Limitations

A

Strengths
* Useful in studying stages of sleep
* Diagnosis of epilepsy (characterised as random bursts of activity in brain, can see on screen)
* High temporal resolution (single millisecond delay)
* Shows real world usefulness of technique

Limitations
* Generalised data received
* Not useful for pinpointing exact source of neural activity
* Cannot distinguish activities originating in different but adjacent areas (next to each other)

61
Q

ERPs Strengths and Limitations

A

Strengths
* More specific measurement of neural processes
* Excellent temporal resolution (derived from EEG) compared to fMRI
* Used to measure cognitive functions and deficits
* Examples- Allocation of attentional resources, maintenance of working memory

Limitations
* Lack of standardisation in methodology in different research studies
* Difficult to confirm findings
* Background noise, external materials must be eliminated (Extraneous variables)
* Not always easily achievable to do so

62
Q

Post-mortem examinations Strengths and Limitations

A

Strengths
* Important for early understanding of key processes in brain before neuroimaging
* Broca and Wernicke used this technique to establish links between language, brain and behaviour
* Used to study HM’s brain, identify areas of damage, associate with memory deficits he had
* Continues to provide useful information

Limitations
* Causation difficult to establish, observed damage may not be linked to deficit
* Could be other unrelated trauma or decay
* Ethical issues, more specifically consent
* May not be able to provide informed consent
* HM could not form memories, not able to provide consent, still was conducted upon
* Challenges usefulness in psychological research

63
Q

Biological Rhythms

  • What is an EP
  • What is an EZ
  • How do these effect the body?
  • What are the three types of rhythms?
  • How long do each last?
A
  • Exert influence on way body systems behave
  • Governed by Endogenous Pacemakers (EP) and Exogenous Zeitgebers (EZ)
  • EP are the bodies internal biological “clocks”
  • EZ are external changes in the environment
  • Ultradian Rhythms (Shorter than a day)
  • Infradian Rhythms (Longer than a day)
  • Circadian Rhythms (About a day)
64
Q

Circadian Rhythms

  • Definition
A

Last around 24 hours, examples include sleep wake cycle and core body temperature. Co-ordinates some of bodies basic processes (heart rate, digestion, hormone levels).

65
Q

Sleep / Wake Cycle

  • How is EZ and EP linked to the sleep/wake cycle?
A
  • Daylight (EZ) influences our sleep wake cycle
  • Also governed by an EP, Suprachiasmatic Nucleus (SCN)
  • Located above optic chiasm (Provides info from eye about light)
  • Light (EZ) can reset the SCN (EP)
66
Q

Siffre’s cave study (1962,1972)

  • Procedure
  • Findings
  • Conclusion
A
  • Spent time underground in caves
  • Deprived of natural light, provided with food and drink
  • One time for 2 months, next time for 6 months
  • Found his “free running” bio rhythm went beyond 24 hours (25 hours)
  • Continued to fall asleep and wake up on regular schedule
67
Q

Aschoff and Wever (1976)

  • Procedure
  • Findings
  • Conclusion
A
  • Group spent 4 weeks in bunker, deprived natural light
  • All but one had circadian rhythm between 24 and 25 hours (One had 29 hours)
  • This and Siffre suggest “natural” sleep/wake cycle longer than 24 hours
  • Cycle entrained by EZ associated with our 24-hour day (Daylight hours, typical eating times)
68
Q

Folkard et al (1985)

  • Procedure
  • Findings
  • Conclusion
A
  • Folkard et al (1985), 12 people live dark cave 3 weeks
  • Go to bed 11:45PM wake up 07:45AM, researchers sped up clock they viewed (Ppt unaware)
  • Only one participant comfortably adjusted to new regime
  • Suggests existence strong free running circadian rhythm
  • Cannot be easily overridden by EZ
69
Q

Evaluation for Circadian Rhythms

A
  • Shift work (Boivin et al 1996, Knutsson 2003)
  • Correlational Methods (Counterpoint, Solomon 1993)
  • Medical treatment (Bonten et al 2015)
  • Individual Differences (Charles et al 1999, Duffy et al 2001)
  • Shifting of the school day (Wolfson and Carkadon 1998)
  • Extraneous Variables (Siffre 1962)
70
Q

Shift work (Boivin et al 1996, Knutsson 2003)

A
  • Provides understanding of consequences when rhythm disrupted (desynchronisation)
  • Boivin et al (1996), night workers experience period of reduced concentration around 6AM
  • Mistakes and accidents more likely
  • Knutsson (2003), relationship between shift work and poor health
  • Shift workers 3 times more likely to develop heart disease
  • Real World economic implications, how to best manage worker productivity
71
Q

Correlational Methods (Counterpoint, Solomon 1993)

A
  • Difficult to establish whether desynchronisation is actually a cause of negative effects
  • May be other factors, Solomon (1993) high divorce rates due to deprived sleep and missing important family events
  • Suggest may not be bio factors that create consequences associated with shift work
72
Q

Medical treatment (Bonten et al 2015)

A
  • Research into circadian rhythms may improve medical treatments
  • Circadian rhythms coordinate bodies basic processes, rise and fall during day
  • Field of Chromotherapeutic (how medical treatment administered way that corresponds to their bio rhythms)
  • Aspirin most effective last thing at night, it reduces risk of heart attacks (most likely occur in morning)
  • Timing of taking aspirin matters, Bonten et al (2015) supports this
  • Suggests circadian rhythm research helps to increase the effectiveness of drug treatments
73
Q

Individual Differences (Charles et al 1999, Duffy et al 2001)

A
  • Small sample sizes, hard to generalise
  • Sleep wake cycles vary from person to person
  • Charles et al (1999) found individual differences in sleep wake cycle varying from 13 to 65 hours
  • Jeanne Duffy et al (2001), some people natural preference to sleep early wake early (“larks”) others opposite (“owls”)
  • Difficult to use this data, low external validity
74
Q

Shifting of the school day (Wolfson and Carkadon 1998)

A
  • Wolfson and Carkadon (1998) recommended school day start later to fit typical teen sleep pattern
  • Better performance at school, less sleep deprived, reduced caffeine dependence
  • Disruptive to parents and teachers, limits extra-curricular activities after school, may impact family life
  • Could not affect sleep deprivation at all, sleep later
  • Suggest later start may produce benefits, not always a practical alternative
75
Q

Extraneous Variables (Siffre 1962)

A
  • Siffre not completely deprived of light
  • Had artificial light, may have influence on results
76
Q

Infradian Rhythms

  • Definition
A

Lasts more than 24 hours, examples include the menstrual cycle and seasonal affective disorder (SAD)

77
Q

The menstrual cycle

  • What is this governed by?
  • How long is a typical cycle?
  • What hormones rising causes ovulation?
  • What is ovulation?
A
  • Governed by monthly changes in hormone levels which regulate ovulation
  • Typical cycle around 28 days to complete (24-35 normal)
  • Rises of oestrogen levels causes ovulation
78
Q

Synchronising the menstrual cycle

  • What did Stern and McClintock 1998 demonstrate?
  • What was the procedure?
  • What did they discover?
A
  • Stern and McClintock (1998) demonstrated how menstrual cycles may sync as a result of the influence of pheromones
  • 29 women with history of irregular periods, samples pheromones gathered from 9 of them
  • Cotton pad placed on armpit at different stages of their menstrual cycle
  • Worn for 8 hours, treated with alcohol and frozen
  • Rubbed on upper lip of other 20 women
  • Day one pad from start of menstrual cycle applied, day two pad from 2nd day of menstrual cycle applied etc
  • 68% women experienced changes to their cycle, closer to cycle of “odour donor”
79
Q

Seasonal affective disorder (SAD)

  • What is this disorder?
  • What is this also referred as?
  • What system is it diagnosed under?
  • What is implicated in the cause of SAD, describe how
A
  • Depressive disorder, seasonal pattern (symptoms triggered in winter months specifically)
  • Also referred to as “winter blues”, diagnosed as mental disorder in DSM-5
  • Melatonin implicated in the cause of SAD
  • During night pineal gland secretes melatonin till dawn when there is increase in light
  • During winter, lack of light in morning means secretion of melatonin continues for longer
  • Thought to have knock off effect on serotonin production (lower levels produced)
  • Lower levels of serotonin linked to onset (start) of depressive symptoms
80
Q

Evaluation for Infradian Rhythms

A
  • Evolutionary basis
  • Methodological limitations (Trevathan et al 1993)
  • Real World Application (Rohan et al 2009)
81
Q

Evolutionary basis

A
  • Strength of menstrual synchrony, may be explained by natural selection
  • Advantageous for women to menstruate together, pregnant same time
  • Allow babies who lost their mothers to access breast milk, increase survival
  • Suggest it’s an adaptive strategy
82
Q

Methodological limitations (Trevathan et al 1993)

A
  • Many factors may effect change to menstrual cycle
  • Stress, change to diet, exercise etc
  • Confounding variables
  • May explain why replication has led to different findings (Trevathan et al 1993)
83
Q

Real World Application (Rohan et al 2009)

A
  • Light box therapy, effective treatment for SAD
  • Box that stimulates very strong light to reset body’s internal clock
  • Studies show this helps reduce effects of SAD in 80% of people (Sanassi 2014)
  • Preferred over antidepressants, safer
  • However, it can produce headaches, eyestrain
  • Rohan et al (2009) recorded relapse rates over successive winters of Light box therapy compared to CBT
  • 46% Light Box Therapy compared to 27% CBT
84
Q

Ultradian rhythms

  • Definition
A

Lasts less than 24 hours, examples include the stages of sleep (sleep cycle)

85
Q

Stages of sleep

  • How long do they each last?
  • How are they each characterised, how are they monitored?
  • Describe the 5 stages of sleep
  • Fill in the Image
A
  • 5 distinct stages, altogether last around 90 minutes
  • Each stage characterised by different level of brainwave activity, monitored with EEG
  • Stage 1- Light sleep, person easily woken, brain waves high frequency short amplitude (alpha waves)
  • Stage 2- Alpha waves continue, occasional random changes (sleep spindles)
  • Stage 3 and 4- Deep sleep or slow wave sleep (SWS), brain waves lower frequency higher amplitude (delta waves), difficult to wake someone at this point
  • Stage 5 (REM sleep)- Body paralysed, brain activity resembles that of awake brain, brain produces theta waves, eyes move around, rapid eye movement (REM), Dreams experienced during REM sleep, could occur in deep sleep
86
Q

Evaluation for Ultradian Rhythms

A
  • Improved understanding (Cauter et al 2000)
  • Individual differences (Tucker et al 2007)
  • The sleep lab
87
Q

Improved understanding (Cauter et al 2000)

A
  • Gained an improved understanding of age-related changes in sleep
  • SWS reduces with age, growth hormone mostly produced during SWS, reduced in older people
  • Eve van Cauter et al (2000), sleep deficit may explain issues in old age such as reduced alertness
  • To increase SWS, relaxation medication used
  • Suggest knowledge of ultradian rhythms has practical value
88
Q

Individual differences (Tucker et al 2007)

A
  • Significant variation between people
  • Tucker et al (2007), large differences between ppts duration of each sleep stage (particularly stage 3 and 4)
  • This research suggests these differences likely to be biologically determined
  • Makes it difficult to describe “normal sleep” in a meaningful way
89
Q

The sleep lab

A
  • Control over extraneous variables
  • Researcher can exclude temporary variables such as noise or temperature
  • Increased internal validity, more confident of casual effects
  • Attached to machinery, invasive, may not represent ordinary sleep patterns
  • May be best to conduct studies in ppts own home, compared this with recordings made in lab settings
90
Q

Superchiasmatic Nucleus (SCN)

  • What is the SCN
  • How is it influential?
  • How does SCN receive info about light?
  • How do bio clocks adjust during sleep?
A
  • Tiny bundle of nerve cells located in hypothalamus in each hemisphere
  • Influential in maintaining circadian rhythms (sleep/wake cycle)
  • Nerve fibres connected to eye, cross optic chiasm on their way to left and right visual area of cerebral cortex
  • SCN lies above optic chiasm, receives info about light directly from this
  • Continues even when eyes are closed, enables adjustment of bio clocks whilst asleep
91
Q

EP and the sleep/wake cycle

  • What is an EP, what does it stand for?
  • Give an example
A
  • Internal body clocks that regulate our bio rhythms
  • Includes the influence on SCN on the sleep/wake cycle
92
Q

Animal Studies and the SCN (DeCoursey et al 2000, Ralph et al 1990)

  • Outline DeCoursey et al (2000)
  • Outline Ralph et al (1990)
A
  • DeCoursey et al (2000) destroyed SCN connections in brains of 30 chipmunks
  • Returned to natural habitat, observed for 80 days
  • Found sleep/wake cycle disappeared, significant proportion killed by predators (awake, vulnerable when they should be asleep)
  • Ralph et al (1990) bred “mutant” hamsters (Had 20-hour sleep/wake cycle)
  • SCN cells from foetal tissue transplanted into brain of normal hamsters, cycles defaulted to 20 hours
93
Q

The Pineal gland and Melatonin

  • What passes info to the pineal gland?
  • What info does it pass?
  • Where is the pineal gland located?
  • What does pineal gland do?
  • What is melatonin suggested to be?
A
  • SCN passes info on day length and light it receives to pineal gland (located behind hypothalamus)
  • During night, pineal gland increases production of melatonin (chemical that induces sleep, inhibited during wakefulness)
  • Melatonin suggested as casual factor in SAD
94
Q

EZ and the Sleep/Wake Cycle

  • What is an EZ, what does it stand for?
  • What does it do, what does this show?
A
  • External factors in environment that rest bio clocks through process called entrainment
  • Free running bio cycle brought into line by environmental cues
  • Shows there is an interaction of internal and external factors
95
Q

Light (Campbell and Murphy 1998)

  • What can light do, what role does it take in this case?
  • What does it have an indirect influence on?
  • Outline Campbell and Murphy 1998
  • What does this suggest about light?
A
  • Can reset SCN, plays role in maintenance of sleep/wake cycle
  • Also has indirect influence on key processes such as hormone secretion and blood circulation
  • Campbell and Murphy (1998) demonstrated light may be detected by skin receptor sites even when same info not received by eyes
  • 15 ppts woken various times, light pad shone on back of knees
  • Researchers managed to produce deviation in ppts usual sleep/wake cycle of up to 3 hours in some cases
  • Suggests light is powerful EZ may not need to rely on eyes to exert influence on brain
96
Q

Social Cues

  • What do we know about new borns sleep/wake cycle?
  • When do circadian rhythms begin?
  • When does entrainment occur, how does this occur?
  • What does Jet lag research suggest?
A
  • New-born babies initial sleep/wake cycle pretty much random
  • 6 weeks of age, circadian rhythms begin
  • 16 weeks rhythms entrained by schedules imposed by parents
  • This includes adult-determined mealtimes and bedtimes
  • Jet lag research suggests adapting to local times (eating, sleeping) effective way entraining circadian rhythm, results in beating jet lag
97
Q

Evaluation for EP

A
  • Beyond the master clock (Damiola et al 2000)
  • Interactionist system
  • Ethics (DeCoursey et al)
98
Q

Beyond the master clock (Damiola et al 2000)

A
  • Limitation of SCN research, may obscure other body clocks
  • Research shows, numerous circ rhythms are in many organs and cells
  • For example, these include lungs, pancreas and skin
  • Influenced by actions of SCN, also act independently
  • Damiola et al (2000), changing feeding patterns in mice, alter circ rhythms of cells in liver (up to 12 hours), leaving rhythm SCN unaffected
  • Suggest other complex influences on sleep/wake cycle
99
Q

Interactionist system

A
  • Limitation, EP cannot be studied in isolation
  • Total isolation studies (Siffre) extremely rare
  • Siffre also used artificial light, could have rests bio clock
  • Everyday life, EP and EZ interact, make little sense to separate for purpose of research
  • Suggest researches attempting to isolate internal pacemakers produce research with lower validity
100
Q

Ethics (DeCoursey et al)

A
  • Animal studies justified in this case, similar mechanism across species
  • Existence of SCN and pineal gland in hamster or chipmunk for example
  • Generalisations can be made to human brain, mammalian brain similar structure
  • Bio level, evolved as adaptive mechanisms in all species
  • No protection from harm, DeCoursey et al (exposed to risk, sleep/wake altered, killed by predators)
  • Suggests studies that place animals at risk difficult to justify
  • Research is applicable to human sleep/wake cycle, researchers should find alternate method of investigating EP without endangering animals
101
Q

Evaluation of EZ

A
  • Environmental observations
  • Case Study Evidence (Miles et al 1977)
  • Age-related insomnia (Duffy et al 2015, Hood et al 2004)
102
Q

Environmental observations

A
  • Limitation, EZ not have same effect in all environments
  • People live in Arctic Circle, similar sleep patterns all year round despite 6 months almost total darkness
  • Suggests sleep/wake cycle primarily controlled by EP, able to override environmental changes in light
103
Q

Case Study Evidence (Miles et al 1977)

A
  • Limitation, evidence challenge’s role of EZ
  • Miles et al 1977, study of young man, blind from birth, abnormal circ rhythm (24.9 hours)
  • Despite exposure social cues (regular mealtimes), could not be adjusted
  • Suggests social cues alone not effective in resetting bio rhythm
104
Q

Age-related insomnia (Duffy et al 2015, Hood et al 2004)

A
  • Evidence suggests poorer quality sleep when people get older
  • 30% individuals over 60 have chronic insomnia
  • May be due to natural changes in circ rhythms, can result in sleeping earlier, experience broken sleep-in night (Duffy et al 2015)
  • Medication given usually to increase melatonin levels (sleeping tablets)
  • Other studies suggest EZ more responsible for changes to sleep amongst older people
  • Hood et al (2004) found management of insomnia improved, more active more exposure to natural light
  • Suggests changes in lifestyles (EZ), just as likely to cause age-related insomnia as internal, bio changes
  • Recommendation for EZ may not be possible, lack of social contacts, disabilities