Chemotherapy 16-22

Question 1

Erlotinib, Gefitinib, Brigatinib

Answer 1

ET, SDR

EGFR TKIs (oral)

MOA: blocks EGFR TK

AE: Rash, Diarrhea, Steven-John syndrome

Question 2

Lapatinib

Answer 2

have HER sit on my LAP CHap

HER 2 / EGFR TKI

MOA: blocks HER2 / EGFR TKI

AE: Cardiotoxic, hepatotoxic

Question 3

Imatinib, dasatinib, nilotinib

Answer 3

grab DIN with BCR and QHG

BCR Ab1 TKI

MOA: blocks BCR Ab1 TK

AE: GI, Hepatoxicity, QT prolongation (nilo - BBW)

Question 4

Sunitinib

Answer 4

HTH and VEG grow in the SUN

VEGFR TKI

MOA: block VEGR TK

AE: Hepatoxicity (BBW)
-HTN, Thromboembolism
(stimulates NO)

Question 5

Cetuximab

Answer 5

HERG is wearing a TUX

MOA: MAB to EGFR

AE: Rash, GI, Hypomg

Question 6

Trastuzumab

Answer 6

H and C is trash

MOA: MAB to HER2

AE: Cardiotoxic

Question 7

Bevacizumab

Answer 7

BEV and VEG have PTH

MOA: MAB to VEGFR

AE: HTN, Thromboembolism, Poor wound healing