PK Flashcards
1
Q
Fluid Compartments
A
TBW 60%
ECF 20% and ICF 40%
Plasma 5% and ISF 15%
2
Q
Vd =
A
Dose / Cpo
3
Q
Vd larger than body
A
Happens when bound to tissue, accumulates in fat,
Vd is decreased when bound to plasma proteins
4
Q
half life =
A
0.693 / k
5
Q
LD =
A
CPss (Vd) / F
6
Q
MD =
A
CL*VD / F
7
Q
CL =
A
ke * VD
8
Q
CLR =
A
fu * GFR
9
Q
CLR > fu*GFR =
CLR < fu*GFR =
A
filtered and secreted
filtered and reabsorbed
