Squamous cell carcinoma

Question 1

Locally […] malignant tumour of epidermal […] .

SCCs can cause […] , tenderness or bleeding and grow over weeks or months. SCCs sometimes […] , which can be fatal.

Answer 1

invasive, keratinocytes
pain
metastasise

Question 2

RFs
- Type […] or […] skin (fair skin which always burns and never or rarely tans)
- History of frequent or severe previous […]
- […] occupation or hobbies
- Personal or family history of skin cancer
- Immunosuppression, especially following an organ transplant
- […]
- […] skin conditions such as Actinic Keratosis or Bowen’s Disease.
- Older age
- Male sex

Answer 2

I, II
sunburn
Outdoor
Smoking
Premalignant

Question 3

Bowen’s Disease is also known as […] SCC or SCC […] […] . It is pre-malignant as tumour cells are confined to the […].

Bowen’s Disease appears as an irregular, red, […], […] plaques classically located on areas of sun exposed skin.

Answer 3

Intraepidermal
in Situ
epidermis
keratinised, scaly

Question 4

Mx
- Surgical excision
- […] and […]
- […] micrographic surgery if the SCC is in a […] sensitive area, is […]-defined or recurrent. This involves examining the excised tissue under the microscope as it is removed to ensure all the cancerous cells are removed whilst preserving the maximum amount of healthy tissue.
- Cryotherapy
- Radiotherapy if surgery is inappropriate

Answer 4

Curettage, cautery
Mohs
cosmetically, ill

Question 5

Features
- […], […]-defined red nodule with […] and ulceration. They often occur on sun exposed areas of skin such as the face, scalp, ears, hands and shins.

Answer 5

irregular, ill, scale

Question 5

Features
- […], […]-defined red nodule with […] and ulceration. They often occur on sun exposed areas of skin such as the face, scalp, ears, hands and shins.

Answer 5

irregular, ill, scale

Question 6

Prognosis is very favourable (a 5 year survival of […]%) if the SCC is detected early.

Answer 6

99