LRI Pharmacology Flashcards
Azithromycin, Erythromycin, & Clarithromycin
Macrolides; Use on ATYPICALS; resistant to S. pneumoniae; QT prolongation
Penicillins + beta lactamase inhibitor (drug combo names)
Amoxicillin/Clavulanate (PO only); Ampicillin/Sulbactam ; Pip/Tazo (IV only)
Cefuroxime, Cefpodoxime, Cefdinir, Ceftriaxone
Cephalosporin’s; no Atypical;
Acute Exacerbation of Chronic Bronchitis (ACEB) 3 microbes and TX
S. pneumoniae, M. catarrhalis, H. influenza; if PT is moderately ill with cough and purulent sputum give Macrolides 3-5 days/5-7 hospitalized
Treatment for HAP or VAP
Vancomycin or linezolid
+ Pip/Tazo or Cefepime or ceftazidime
+ cipro or levofloxacin
What is the most common drug used to treat outpatients for COVID-19;
Remdisvir; IV only
How soon from SX onset should you give Remdisvir for COVID TX?
Within 7 days
Why cant Molnupiravir be given to patients under 18y/o?
It will cause bone and cartilage toxicity
This COVID-19 drug can be used in patients over 12y/o as outpatient tx; should be administered within 5 days of SX onset; and has multiple drug-drug interactions
Paxlovid
What COVID-19 tx is contraindicated for patients who are currently breastfeeding?
Molnupiravir
What COVID-19 drug is proven to shorten time to clinical improvement only?
Remdisvir
What corticosteroid should be used in TX for COVID-19
Dexamethasone
What are the two respiratory fluoroquinolones that can be used for empirical tx of pneumonia because of their activity against S. pneumoniae?
Levofloxacin, Moxifloxacin
Why is Ciprofloxin not considered a respiratory fluoroquinolone?
It lacks activity against S. pneumoniae
When should an anti-viral or neuramidase inhibitor be administered for flu exposure?
most effective when started as early as possible
-ideally within 48hrs
