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Bisc 414 > Lecture 10 > Flashcards

Lecture 10 Flashcards

1
Q

Spleen

A
  1. Removal of spent RBCs
  2. Immune surveillance of the Blood
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2
Q

Microanatomy of the Spleen

A
  1. Capsule: encases the spleen
  2. Trabeculae: sections and supports the spleen
  3. White Pulp PALS Marginal Zone: Immune System
  4. Red PULP Macrophage: Recycling ‘spent’ RBCs
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3
Q

Capsule

A

Fibrous sheath that surrounds the spleen

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4
Q

Trabeculae

A
  1. Fibrous projections that extend down from the capsule
  2. Provides structural support for the sinusoidal organ
  3. Blood vessels are embedded within hilar trabeculae
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5
Q

White Pulp

A

Marginal Zone
1. Marginal Zone Sinuses
2. Peripheral White Pulp or Follicle
3. Germinal Centers
4. Periarteriole Lymphoid Sheath

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6
Q

Red Pulp

A
  1. Vascular Sinusoid
  2. Splenic Cords (Cords of Billroth)
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7
Q

Pathway of Antigens

A
  1. Course through Splenic and Central Arteries
  2. Portion of splenic blood flow runs through the white pulp
  3. Enter the Marginal Zone Sinuses
  4. Antigens
    a. Screened by Marginal Zone B-Cells
    b. Trapped and processed by Dendritic Cells
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8
Q

Activated B-Cells

A
  1. Leave the Marginal Zone Sinus
  2. Trek to the Peripheral White Pulp
  3. Some develop Germinal Centers
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9
Q

Activated (Mature) Dendritic Cells

A
  1. Leave the Marginal Zone
  2. Trek to the PALS
  3. Present Antigens to naïve T-Cells
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10
Q

Stave Cells

A
  1. Lines the vascular walls
  2. Forms a longitudinal slotted filter
  3. Restricts the vascular recovery of ‘spent’ RBCs
    a. increased diameter due to swelling
    b. diminished flexibility
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11
Q

Mucosa-Associated Lymphatic Tissues

A
  1. Tonsils: back of throat
  2. Adenoid: posterior nasal cavity
  3. Appendix: Ig intestine
  4. Peyer’s Patches: small intestine
  5. Lymphoid Follicles: where needed
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12
Q

Mucosa

A

Tissues that line the endodermal surfaces of your body
1. Nasal cavity
2. Oral cavity
3. Pulmonary tract
4. Urinary-Genital tracts
5. Digestive tract

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13
Q

MALTS

A

Present in the mucosal connective tissue

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14
Q

MALTS (General Features)

A
  1. Mucosal surfaces are primary sites of pathogen entry
  2. MALTs are positioned within the connective tissue of musoca
  3. MALTs protect against exposure to external environments
  4. Organizational complexity varies form site to site
  5. Constitutive or induced
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15
Q

Peyer’s Patches

A
  1. Located in the wall of the ileum of the small intestine
  2. Well-organized lymphoid follicles
    Humans: clusters of 30-40 individual follicles
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Bisc 414 (21 decks)

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