Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

phar 262 > 4 Part 2: Bone Agents > Flashcards

4 Part 2: Bone Agents Flashcards

1
Q

methylene diphosphonate akas

A

MDP or medronate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

hydromethylene diphosphonate akas

A

HDP, HMDP, oxidronate
or TechneScan HDP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what do both the MDP and HDP have in their kits?

A

complexing agents, reducing agents, antioxidants, and inert atmosphere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

how long is the incubation period for MDP? HDP?

A

MDP - 10 minutes
HDP - 30 seconds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MDP/HDP + Tc = (non/polar) RP

A

polar RP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the difference between MDP and HDP?

A

HDP has the extra OH- group

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

which pharm is tridentate and which is bidentate?

A

HDP - tri
MDP - bi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

biodistribution of MDP/HDP

A

bone, kidneys/bladder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

method of localization

A

chemisorption - binding to Ca2+ on bone crystals on bone surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

osteo(blast/clast) removes phosphonate compounds from the blood.

A

osteoblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

higher degree of uptake in (HA/ACP) than in (HA/ACP)

A

higher degree of uptake in ACP than in HA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

where do you see biodistribution of free pert?

A

thyroid, gastric mucosa, salivary glands, and choroid plexus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

where do you see hydrolyzed reduced Tc/colloid formation?

A

liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

where do you see increased aluminum concentrations in eluate/plasma?

A

liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

long term steroid use

A

decreased bone uptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

cytotoxic therapy in breast cancer patients

A

diffuse calvaria uptake

17
Q

chemotherapy agents in kids

A

increased renal uptake

18
Q

effects of iron

A
  • focal increased soft tissue uptake at iron-dextran injection
  • decreased bone uptake with excessive plasma iron levels
  • spleen uptake in patients with sickle cell disease (increase iron levels)
19
Q

What is the name for altered biodistribution due to a drug or other medical treatment?

A

iatrogenic effects

20
Q

critical organ for HDP? MDP?

A

HDP - bone surface
MDP - bone surface or bladder wall (values are very close)

21
Q

use of MDP/HDP

A

assessing altered osteogenesis due to various pathologies

22
Q

dose of MDP/HDP

A

740-1110 MBq

phar 262 (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions