4 Part 3: Myocardial Perfusion Agents

Question 1

perfusion

Answer 1

uptake relative to blood flow

Question 2

Mibi aka?

Answer 2

methods-isobutyl-isonitrile, sestamibi, or cardiolite

Question 3

what is found in the Mibi kit that is a precursor to the complexing agent?

Answer 3

tetrakis Mibi copper tetrafluoroborate

Question 4

what does the copper do in the Mibi kits?

Answer 4

it keeps the Mibi stable during storage

Question 5

what are the components in the Mibi kits?

Answer 5

• precursor to complexing agent
• complexing agent
• reducing agent
• buffer and transfer ligand
• stabilizer
• transfer ligand
• bulking agent
• inert atmosphere

Question 6

describe the structure of the 99mTc-Mibi RP.

Answer 6

central 99mTc surrounded by 6 lipophilic Mibi molecules

Question 7

what is the normal distribution of Mibi throughout the body?

Answer 7

hepatobiliary > kidney > heart > spleen > lungs > muscle

Question 8

critical organ of Mibi

Answer 8

upper large intestinal wall

Question 9

how does Mibi get cleared?

Answer 9

hepatobiliary system and kidneys

Question 10

where do we see higher clearance?

Answer 10

hepatobiliary

Question 11

Mibi is (lipophilic/hydrophilic)

Answer 11

lipophilic

Question 12

% of Mibi is taken up in the heart at first pass?

Answer 12

66%

Question 13

uptake of Mibi at rest by the heart? at stress?

Answer 13

rest = 1.0% of injected dose
stress = 1.4% of injected dose

Question 14

99mTc-Tetrofosmin akas?

Answer 14

tetrofosmin, myoview

Question 15

what does disodium sulfosalicylate do?

Answer 15

chelates any Al3+ or other metals