RENAL Introduction to Renal Physiology and Clinical Science

Question 1

Structure of kidneys

Answer 1

SEE LEC SLIDES

Question 2

What type of reflex is involved in glomelular filtration?

Answer 2

Myogenic reflex

Question 3

What type of feedback is involved in glomerular filtration?

Answer 3

Tubuloglomerular feedback

Question 4

How can we measure GFR?

Answer 4

After intravenous injection of a tracer, which is excreted from the body by glomerular filtration only, GFR can be measured
from its plasma clearance, i.e. excretion rate relative to the plasma concentration or from the ratio between the injected dose
and the area under the plasma concentration curve. Plasma clearance of 51Cr-EDTA involves a single intravenous injection
followed by blood sampling from 2 or 3 to 4, 5 or 24 h. The lower the GFR, the later is blood sampling needed.