Cholesterol-uptake Inhibitors Flashcards
1
Q
What class of drug is Ezetimibe?
A
Selective cholesterol-absorption inhibition
2
Q
What is the indication of Ezetimibe?
A
Hypercholesterolemia
3
Q
What is the mechanism of action of Ezetimibe?
A
Inhibits NPC1L1 transporter at brush border of small intestine. Hepatic LDL receptor expression increases.
4
Q
What are the adverse effects of Ezetimibe?
A
Abdominal pain, GI upset, Angioedema
5
Q
What are the drug-drug interactions of Ezetimibe?
A
Statins- risk of rhabdomyolysis
6
Q
How is Ezetimibe administered and why?
A
The drug is administered orally, half life of 22 hours.
7
Q
How do you remember Ezetimibie?
A
