Conquest Of Blood Transfusion Flashcards

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1
Q

What was the problem of blood transfusion

A

Immunological compatibility, coagulation, and Storage

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2
Q

First Blood transfusion was done by?

A

Jean Baptiste Dennis, in 1667

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3
Q

What did Jean Baptiste Dennis do?.

A

He transfused a 17yr old boy with 270mls of blood fron the carotid artery of a sheep

Came with no adverse reaction, surprisingly

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4
Q

When was blood transfusion banned in France?

A

17th April 1668, this was because it proved abortive after Jean Baptiste trial.

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5
Q

Who first did man to man transfusion?

A

James Blundell of Guy hospital, 1818

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6
Q

What Did James Blundell do?

A

Had to tranfuse blood with syringe immediately after collecting the blood …

Reason is to avoid blood coagulation and clotting

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7
Q

What happened in 1900

A

Karl Landsteiner discovered the three different blood groups in his laboratory in Vienna.

Explained the adverse reaction of blood, coagulation was due to agglutinin presence

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8
Q

What did M Hustin of Belgium do?

A

He introduced blood preservation using sodium citrate as anticoagulant ,in YEAR 1914

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9
Q

What happened in 1916

A

Rous and Turner prolonged the lifetime of RBC by adding Glucose

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10
Q

Progression of Events.
1667—-➡️ Transfusion using 270mls of carotid blood of sheep

1668(17/04)–➡️ France and other countries were banned from blood transfusion

1818—➡️Man to man transfusion happened in guy’s hospital

1900– ➡️ Karl Landsteiner discovered the blood groups and effect of agglutinin.

1914➡️ Blood preservation using sodium citrate was introduced

1916➡️ Glucose was added to preserve RBC

1937➡️ Blood bank organisation in cook country hospital Chicago.

1943➡️ Blood preservation lasted for 21days due to addition of acid citrate and dextrose.

A

1667➡️ Jean Baptiste Dennis.
1818➡️James Blundell
1900➡️ Karl Landsteiner
1914➡️M.Hustin of Belgium
1916➡️Rous and Turner
1937➡️Benard Fantus
1943➡️Loulit and Mollison

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11
Q

What happened in 1935?

A

Benard Fantus organized a blood bank in cook country hospital Chicago.

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12
Q

What did Loulit and Mollison do in 1943

A

They added acid citrate and dextrose to blood mixture increasing it’s lifespan to 21days

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