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Year Three - Psychiatry > Tricyclic Antidepressant Overdose > Flashcards

Tricyclic Antidepressant Overdose Flashcards

1
Q

What is tricylic antidepressant overdose?

A

It is defined as excessive ingestion of tricyclic antidepressants

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2
Q

Which two tricylic antidepressants are most dangerous to overdose on?

A

Amitriptyline

Dosulepin

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3
Q

What are four risk factors of tricylic antidepressant overdose?

A

Previous Suicide Attempt

Previous Self-Harm

Psychiatric History

Cognitive impairment

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4
Q

Following tricylic antidepressant overdose, when do clinical features tend to present?

A

> 6 hours

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5
Q

What are the clinical features of tricylic antidepressant overdose related to?

A

Anticholinergic toxicity

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6
Q

What are the eleven clinical features of tricylic antidepressant overdose?

A

Dry Mouth/Skin

Blurred Vision

Pupil Dilatation

Urinary Retention

Seizures

Syncope

Irritability

Confusion

Tachycardia

Arrythmias

Hypotension

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7
Q

What are the three investigations used to diagnose tricylic antidepressant overdoses?

A

Blood Tests

Arterial Blood Gas (ABG)

ECG Scan

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8
Q

What two blood test results indicate tricylic antidepressant overdoses?

A

Decreased Potassium Levels

Decreased Magnesium Levels

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9
Q

What ABG result indicates tricylic antidepressant overdose?

A

Metabolic acidosis

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10
Q

What are the three features of tricylic antidepressant overdose on ECG scans?

A

Sinus Tachycardia

Widened QRS Complexes

Prolonged QTc Interval

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11
Q

What dose a QRS complex > 100ms indicate in tricylic antidepressant overdose?

A

Seizure Risk

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12
Q

What dose a QRS complex > 160ms indicate in tricylic antidepressant overdose?

A

Ventricular Arrythmia Risk

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13
Q

What are the two pharmacological management options of tricylic antidepressant overdose?

A

Activated Charcoal

IV Sodium Bicarbonate

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14
Q

When is activated charcoal used to treat tricylic antidepressant overdose?

A

When individuals present within one hour of overdose

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15
Q

How is activated charcoal used to manage tricylic antidepressant overdose?

A

It is used to reduce absorption of the drug

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16
Q

When is IV sodium bicarbonate used to manage tricylic antidepressant overdose?

A

It is the first line management option in cases where hypotension or arrythmias develop

Year Three - Psychiatry (23 decks)

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