Math Fundamentals; Kinetic Schemes

Question 1

dC/dt

Answer 1

rate of change
unit: concentration/time

Question 2

K

Answer 2

zero-order rate constant

Question 3

k

Answer 3

First-order rate constant

Question 4

A

Answer 4

amount

Question 5

2mg = _______ mcg

Answer 5

2000 mcg

Question 6

2ng/mL = ________ mcg/L

Answer 6

2mcg/L

Question 7

2 mcg/mL = ________ mg/L

Answer 7

2mg/L

Question 8

60 mL/min = ______ L/h

Answer 8

(60mL/min)*60/1000 = 3.5 L/h

Question 9

Under zero-order kinetics, there is a constant ______ of drug being processed per unit of time.

Answer 9

amount (A)

Question 10

First-order kinetics refers to a constant _______ of a drug being processed per unit of time

Answer 10

fraction

Question 11

Under zero-order kinetics, the rate of change (dC/dt) is _________ drug concentration.

Answer 11

independent of

Question 12

Zero-order rate constant has units in _________

Answer 12

amount/time

Question 13

Under first-order kinetics, the rate of change (dC/dt) is _________ drug concentration.

Answer 13

proportional to

Question 14

First-order rate constant has units in _______

Answer 14

1/time

Question 15

If the elimination of a drug follows the zero-order kinetics, its elimination rate should be _______ (a constant/in proportion to the concentration)

Answer 15

a constant

Question 16

If the elimination of a drug follows the first-order kinetics, its elimination rate should be ________ (a constant/in proportion to the concentration)

Answer 16

in proportion to the concentration

Question 17

Under zero-order kinetics, the concentration-time profile plotted on a rectilinear graph paper should appear to be a _______ (straight line/inward curve/outward curve)

Answer 17

straight line

Question 18

Under first-order kinetics, the concentration-time profile plotted on a rectilinear graph paper should appear to be a __________ (straight line/inward curve/outward curve)

Answer 18

inward curve

Question 19

Under zero-order kinetics, the concentration-time profile plotted on a semi-log graph paper (with log-transformed Y-axis) should appear to be a ________ (straight line/inward curve/outward curve)

Answer 19

outward curve

Question 20

Under first-order kinetics, the drug concentration has a ______ (linear/log-linear) relationship with time

Answer 20

log-linear

Question 21

Linear kinetics is always the _______ order kinetics

Answer 21

first

Question 22

Under zero-order kinetics, rate of change is _______ (proportional to/independent of) amount of drug in the body

Answer 22

independent of