chemo

Question 1

what type of cytotoxic agent is cylophasmamide

Answer 1

alklyating

Question 2

SE cyclophosphamide

Answer 2

myelosuppresion

Question 3

what type of chemo is bleomycin + anrthracyclines

Answer 3

cytotoxic antibodies

Question 4

SE bleomycin

Answer 4

lung fibrosis

Question 5

SE anthracyclines (eg doxorubicin)

Answer 5

cardiomyopathy

Question 6

what type of chemo is methotrexate + 5FU

Answer 6

antimetabolites

Question 7

SE methotrextae

Answer 7

myelosuppression, mucositis, liver fibrosis, lung fibrosis

Question 8

SE 5-FU

Answer 8

myelosuppression, mucositis, dermatitis

Question 9

what type of chemo is vincristine/ vinblastine

Answer 9

microtubule

Question 10

SE vincristine

Answer 10

peripheral neuropathy + paralyctic ileis

Question 11

SE cisplatin

Answer 11

ototoxic, peripheral neuropathy

Question 12

what causes neutropenic sepsis

Answer 12

chemo therapy

Question 13

when does neutropeanic sepsis occur

Answer 13

7-14 days after starting cancer therapy

Question 14

criteria neutropenic sepsis

Answer 14

neutrophils <0.5 + temp 38 OR clinical sepsis

Question 15

organism neutropenic sepsis

Answer 15

coag neg, gram +ive eg staph epi

Question 16

when is prophylaxis for neutropenic sepsis started

Answer 16

if neutrophils expected to drop to <0.5

Question 17

what is prophylaxis for neutropenic sepsis

Answer 17

fluoroquinolone

Question 18

mx neutropenic sepsis

Answer 18

piperacillin with tazobactam (Tazocin)

Question 19

when is mx for neutropenic sepsis started

Answer 19

straight away, do not wait for blood if suspected

Question 20

if still unwell with neutropenic sepsis after 48 hours what is done

Answer 20

meropenam +/- vanc

Question 21

if still unwell 4-6 days later with neutropenic sepsis what is done

Answer 21

invx for fungal infection

Question 22

what can cause tumour lysis syndrome

Answer 22

combination chemo // (can occur independently or with steroids but rare)

Question 23

what prophylaxis is given for high risk tumour lysis syndrome patients

Answer 23

IV allopurinol or rasburicase

Question 24

prophylaxis low risk tumour lysis syndrome patients

Answer 24

oral allupirinol

Question 25

what is tumour lysis syndrome

Answer 25

breakdown of tumour cell –> bad things

Question 26

metabolic changes tumour lysis syndrome

Answer 26

raised K // raised phosphate // raised uric acid // low calcium

Question 27

diagnosing tumour lysis

Answer 27

metabolic changes plus 1 of: raised creatine // arrythemia // seizure

Question 28

what clinical picture would indicate tumour lysis syndrome

Answer 28

chemo cancer patient + AKI + high phosphate, uric acid