14.1 Poisoning Flashcards
loperamide
-class
-useful side effect
-opioid agonist
-targets GI myenteric plexus so treats diarrhoea
chlorpromazine
-class
-useful side effect
-anti emetic
-sedative so good for anxiety in aplliation
statin primary ands secondary effects
primary- decrease cholesterol
secondary- rhabdomyolysis, myalgia
drugs that can cause myocardial depression
beta blockers
drugs that can cause respiratory depression
opioids
AEDs e.g. carbamazepine
potenital effect of theophylline
arrythmia, convulsion
in management of overdose, what could help prevent absorption? who is this not suitable for?
activated charcoal
drowsy/comatose patients
in management of overdose, what could help elimination?
activated charcoal up to 36 hours
sodium bicarbonate for salicylate poisoning
haemodialysis for small drug Vd
why is forced diuresis NOT recommended for elimination in overdose?
electrolyte imbalance
antidote for opioid overdose
naloxone
antidote for organophosphate poisoning
atropine
fomepizole
treat overdose of methanol, ethylene glycol
PK + PD changes in elderly people to consider
increased fat
decreased water
renal function reduced
hepatic functionalists reduced
reduced first pass metabolsim
extra pyramidal effects
how to use STOPP START
in patients over 65
in conjunction with your clinical judgment
antidote for benzodiazepines
flumazenil
