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Pharm exam 2 > drug main uses (Cholinergic/Anticholinergic) > Flashcards

drug main uses (Cholinergic/Anticholinergic) Flashcards

1
Q

Acetylcholine

A

Musc ag

glaucoma

↓ IOP (acts on musc and nic receptors)

quickly metabolized by AChE

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2
Q

Carbachol

A

Musc ag

glaucoma

↓ IOP (acts on musc and nic receptors)

not quickly metabolized by AchE

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3
Q

Methachoine

A

Musc ag

asthma testing

stimulates muscarinic receptors

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4
Q

Bethanechol (urecholine)

A

Musc ag

stim GI motility and treat urinary retention

stimulates muscarinic receptors

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5
Q

Pilocarpine (Salagen)

A

Musc ag

glaucoma and xerostomia

↓ IOP and ↑ salavary gland secretion

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6
Q

Edrophonium (Tensilon)

A

Rev Chol-i

Dx of Myasthenia Gravis

Increase GI motility, contraction of bladder and relaxation of sphincters, bradycardia and hypotension, increased secretions, ↓ IOP, stimulation of skeletal muscle at low dose and paralysis at high dose, bronchoconstriction

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7
Q

Physostigmine

A

Rev Chol-i

Tx of atropine/Antimuscarinic poisoning

Increase GI motility, contraction of bladder and relaxation of sphincters, bradycardia and hypotension, increased secretions, ↓ IOP, stimulation of skeletal muscle at low dose and paralysis at high dose, bronchoconstriction

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8
Q

Neostigmine (Prostigmin)

A

Rev Chol-i

Tx of Myasthenia Gravis/Reversal of Neuomuscular Blockade

Increase GI motility, contraction of bladder and relaxation of sphincters, bradycardia and hypotension, increased secretions, ↓ IOP, stimulation of skeletal muscle at low dose and paralysis at high dose, bronchoconstriction

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9
Q

Pyridostigmine

A

Rev Chol-i

Tx of Myasthenia Gravis/Reversal of Neuomuscular Blockade/Prophylactic for nerve agents

Increase GI motility, contraction of bladder and relaxation of sphincters, bradycardia and hypotension, increased secretions, ↓ IOP, stimulation of skeletal muscle at low dose and paralysis at high dose, bronchoconstriction

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10
Q

Rivastigmine (Exelon)

A

Rev Chol-i

Tx of Alzheimer’s Disease

Increase GI motility, contraction of bladder and relaxation of sphincters, bradycardia and hypotension, increased secretions, ↓ IOP, stimulation of skeletal muscle at low dose and paralysis at high dose, bronchoconstriction

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11
Q

Donepezil (Aricept)

A

Rev Chol-i

Tx of Alzheimer’s Disease

Increase GI motility, contraction of bladder and relaxation of sphincters, bradycardia and hypotension, increased secretions, ↓ IOP, stimulation of skeletal muscle at low dose and paralysis at high dose, bronchoconstriction

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12
Q

Carbamate Insecticides (Carbaryl)

A

Rev Chol-i

No tx, just a poison to know

Increase GI motility, contraction of bladder and relaxation of sphincters, bradycardia and hypotension, increased secretions, ↓ IOP, stimulation of skeletal muscle at low dose and paralysis at high dose, bronchoconstriction

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13
Q

DFP/diisopropylfurophosphate/Echothiophate

A

Irrev Chol-i

Glaucoma

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14
Q

Organophosphates (Parathion, Malathion)

A

Irrev Chol-i

no tx, just a poison to know

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15
Q

Nerve gases (Sarin, VX, Tabun)

A

Irrev Chol-i

no tx, just a poison to know

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16
Q

Pralidoxime (Protopam)

A

Chol-reactivator

Antidote for organophosphate poisoning

Inhibits and regenerates cholinesterase

17
Q

Sildenafil (Viagra)

A

PDE-5 inhibitor

acquire bonrar

Increase in NO production causes erection

18
Q

Verdenafil (Levitra)

A

PDE-5 inhibitor

acquire bonrar

Increase in NO production causes erection

19
Q

Tadalafil (Cialis)

A

PDE-5 inhibitor

acquire bonrar

Increase in NO production causes erection

20
Q

Atropine (Hycosamine)

A

Anti-chol/anti-musc

Reduce secretions, block vagal reflexes, cardiac stimulant s/p MI, Antidote for Cholinesterase inhibitor/muscarinic agonist overdose, mydriasis and cycloplegia, GI

Tachycardia, slight increase in output, mydriasis, cycloplegia, increased IOP, decreased GI motility, urine retention, reduced sweating, dried secretions, sedation or hallucination

21
Q

Scopolamine (Hyoscine)

A

Anti-chol/anti-musc

Prevention of motion sickness and vertigo

Similar effects as atropine, but more of a CNS depressant

22
Q

Dicyclomine (Bentyl)

A

Anti-chol/anti-musc

Intestinal Antispasmodic

23
Q

Propantheline (Pro-Banthine)

A

Anti-chol/anti-musc

Intestinal Antispasmodic

Few CNS effects

24
Q

Glycopyrrolate (Robinul)

A

Anti-chol/anti-musc

Dry repiratory secretions and inhibit vagal reflexes prior to anesthesiology

25
Q

Ipratropium (Atrovent)

A

Anti-chol/anti-musc

Tx of COPD and Asthma

26
Q

Tiatropium (Spiriva)

A

Anti-chol/anti-musc

Tx of COPD and Asthma

27
Q

Benztropine (Cogentin)

Trihexyphenidyl (Artane)

A

Anti-chol/anti-musc

Tx of Parkinson’s/Parkinsonism

Centrally-acting antimuscarinic

28
Q

Tolterodine (Detrol)
Oxybutynin (Ditropan)
Solifenacin (Vesicare)

A

Anti-chol/anti-musc

Tx of overactive bladder

Decreases urinary incontinence by decreasing muscarinic actions

29
Q

Botulinium Toxin (Botox)

A

Neurotoxin

Ophthalmic disorders, wrinkles, dystonia, excessive sweating and overactive bladder

Decreased release of Ach from autonomic nerve endings and in the neuromuscular junction

30
Q

Pancuronium (Pavulon)

Atracurium (Tracrium)

A

Neuromuscular Blocking Drugs

Relaxation or paralysis of skeletal muscle

31
Q

Succinylcholine (Anectine)

A

Neuromuscular Blocking Drugs

Relaxation or paralysis of skeletal muscle

Initially fasciculations, followed by relaxation and paralysis of skeletal muscles

32
Q

Tropicamide (Mydriacyl)

A

Anti-chol/anti-musc

Pupil dilation for ophthalmologic exam

Pharm exam 2 (16 decks)

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