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19 Skin Pathology > 1.3 Epithelial tumors > Flashcards

1.3 Epithelial tumors Flashcards

1
Q

keratoacanthoma

  • what does it look like
  • how does it progress, what timeframe
A
  • well-differential squamous cell carcinoma
  • cup-shaped tumor with central keratin plug (like a volcano)
  • develops rapidly (2-10 weeks) then regresses spontaneously
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2
Q

seborrheic keratoses

-histological finding

A

-histology hallmark: keratin pseudocysts (“Horncysts”)

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3
Q

seborrheic keratosis

  • clinical finding
  • what is it
A
  • coin-like, stuck-on appearance
  • raised, discolored plaque
  • benign squamous tumor
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3
Q

Acanthosis nigricans

  • clinical findings
  • common locations
  • what associated with? (2)
A
  • “thick, dark” velvet like skin (epidermal hyperplasia)
  • axilla, groin

associated with:

  1. insulin resistance (T2DM)
  2. malignancy (esp gastric carcinoma)
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3
Q

what is it?

-cup-shaped papule with central keratin plug (like a volcano)

A

keratoacanthoma

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4
Q

actinic keratosis

-clinical finding

A
  • aka solar/senile keratosis
  • precursor lesion to squamous cell carcinoma
  • hyperkeratotic, scaly plaque
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6
Q

What skin problems should you suspect a GI tumor?

A
  1. Suspect GI carcinoma in Leser-Trelat sign (sudden multiple seborrheic keratoses)
  2. Suspect gastric carcinoma in acanthosis nigricans
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6
Q

what is it?

  • thick, dark velvet like skin
  • axilla, groin
A

acanthosis nigricans

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7
Q

basal cell carcinoma

-classic appearance (3 things)

A
  1. elevated nodule
  2. central, ulcerated crater
  3. telangiectatic vessels surround it
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8
Q

what is it?

  • coin-like, stuck-on appearance
  • raised, discolored plaque
  • histology hallmark: keratin pseudocysts
A

seborrheic keratosis

(a benign squamous tumor)

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9
Q

actinic keratosis

-histology

A
  • cytologic atypia in lower levels of epidermis
  • blue-gray elastic fibers in dermis from solar exposure (solar elastosis)
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10
Q

classic locations of:

  1. basal cell carcinoma
  2. squamous cell carcinoma
A
  1. upper lip
  2. lower lip

“BS”

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12
Q

skin cancer:

  • list main types
  • which ones most common, which ones most severe?
A
  1. basal cell carcinoma (8/10 frequency)
  2. squamous cell carcinoma (2/10 frequency)
  3. melanoma (rare)

melanoma is most common cause of skin cancer death. other 2 are rarely metastatic.

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14
Q

Leser-Trelat sign

A
  • sudden onset of many seborrheic keratoses (stuck on coins)
  • suggests GI carcinoma
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15
Q

what is it?

  1. elevated nodule
  2. central, ulcerated crater
  3. telangiectatic vessels surround it
A

basal cell carcinoma

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16
Q

basal cell carcinoma:

-histology hallmark

A

-“peripheral palisading” of basal cell nodules

19 Skin Pathology (8 decks)

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