13 - Simple Cortical Circuits

Question 1

What are two model synaptic circuits?

Answer 1

• Glutamate receptor responses
• GABA receptor responses

Question 2

What are two neuronal model circuits?

Answer 2

• Pyramidal cells
• Interneurons

Question 3

Two types of neurons used in simple cortical circuits

Answer 3

• Pyramidal cells
  
  • Glutamatergic
• Interneurons
  
  • GABAergic

Question 4

4 connection types in simple cortical circuits

Answer 4

1. Excitatory
   
   • feedforward
   • feedback
2. Inhibitory
   
   • Feedforward
   • Feedback
3. Somatic
4. Dendritic

Question 5

_______ receptor is a glutamate-operated LGIC (made from GluR1-4) with a linear I-V relationship and an Erev of ~0mV

Charge carries: Na+, some K+ (Ca++ only in receptors missing GluR2)

Answer 5

AMPA receptor is a glutamate-operated LGIC (made from GluR1-4) with a linear I-V relationship and an Erev of ~0mV

Charge carries: Na+, some K+ (Ca++ only in receptors missing GluR2)

Question 6

AMPA receptor is a ___________ (made from _____) with a ___ I-V relationship and an Erev of _____

Charge carries: ____, some (__ only in receptors missing _____\_)

Answer 6

AMPA receptor is a glutamate-operated LGIC (made from GluR1-4) with a linear I-V relationship and an Erev of ~0mV

Charge carries: Na+, some K+ (Ca++ only in receptors missing GluR2)

Question 7

NMDA receptor is a: ___________ (made from ______)

I-V relationship: _____

Erev = ____

Charge carriers: ____, _____, ____

Answer 7

NMDA receptor is a: glutamate operated LGIC (made from NR1 + NR2A-D)

I-V relationship: non-linear (caused by Mg2+ block at neg voltages)

Erev = ~0mV

Charge carriers: Na+, Ca++, K+

Question 8

______ receptor is a: glutamate operated LGIC (made from NR1 + NR2A-D)

I-V relationship: non-linear (caused by Mg2+ block at neg voltages)

Erev = ~0mV

Charge carriers: Na+, Ca++, K+

Answer 8

NMDA receptor is a: glutamate operated LGIC (made from NR1 + NR2A-D)

I-V relationship: non-linear (caused by Mg2+ block at neg voltages)

Erev = ~0mV

Charge carriers: Na+, Ca++, K+

Question 9

Why is the I-V relationship of NMDA nonlinear?

Answer 9

Because there is a Mg++ block of the channel at negative voltages

Question 10

GABA_A - ___________

Charge carriers: _________

Erev = _____

Answer 10

GABA_A - GABA-operated LGIC

Charge carriers: Cl-, HCO3-,

Erev = -65mV

Question 11

______ - GABA-operated LGIC

Charge carriers: Cl-, HCO3-,

Erev = -65mV

Answer 11

GABA_<u>A</u> - GABA-operated LGIC

Charge carriers: Cl-, HCO3-,

Erev = -65mV

Question 12

______ - GABA-activated GPCR

Activates: GIRK (inward rectifier)

Erev = -100mV

Answer 12

GABA_<u>B</u> - GABA-activated GPCR

Activates: GIRK (inward rectifier)

Erev = -100mV

Question 13

GABA_B - ________

Activates: _______

Erev = ______

Answer 13

GABA_<u>B</u> - GABA-activated GPCR

Activates: GIRK (inward rectifier)

Erev = -100mV

Question 14

Pyramidal cell:

• _______ releasing
• Structure?
• Receptors?

Answer 14

Pyramidal cell:

• Glutamate releasing
• Structure?
  
  • Large apical dendrite
  • Large cell body (soma)
  • Axon
• Receptors?
  
  • NMDA, AMPA
  • GABA_A
  • GABA_B

Question 15

Interneuron:

• _____ releasing
• Driven by _______

Answer 15

Interneuron:

• GABA releasing
• Driven by AMPA excitation