Lecture 1 - part 2

Question 1

Albumin and colloid osmotic pressure-overview

Answer 1

Colloid osmotic pressure: osmotic pressure exerted by colloids (plasma proteins) in solution

Question 2

Albumin and colloid osmotic pressure:
Malnutrition vs liver dysfunction

Answer 2

Malnutrition
= Ascites
- The loss of colloid osmotic pressure due to loss in albumin causes hydrostatic pressure/colloid osmotic pressure imbalance, leading to fluid accumulation in the abdominal cavity

Liver dysfunction:
All the albumin and fibrinogen as well as 60-80% of the globulins are formed in the liver (up to 2g per hour or 50g per day!)

Question 3

Conjugated proteins:

Answer 3

> combined with non-protein substances

• Nucleoproteins: histones
• Nucleoproteins: nucleic acid
• Lipoproteins, chromoproteins, phosphoproteins, metalloproteins

Question 4

Cna have metal neurotoxicity if too much metal in metalloproteins

Question 5

Proteoglycans:

Answer 5

(with large negatively charged polysaccharides)
Vitreus humour of eye
Connective tissue