Anabolic Reaction Pt.2

Question 1

What is Adenosine
diphosphoglucose (ADPG)?

Answer 1

A precursor for glycogen
biosynthesis

Question 2

What is Uridine diphosphoglucose
(UDPG)?

Answer 2

Precursor of some glucose
derivatives needed for biosynthesis of important polysaccharides that makes important bacteria
Examples: N- acetylglucosamine, N-acetylmuramic acid

Question 3

Where does the carbon skeleton come from?

Answer 3

Kreb cycle or glycolysis

Question 4

Describe the details of Biosyntyhesis of Fatty Acids

Answer 4

Fatty acids made 2 carbon atoms at a time and Requires Acyl carrier protein (ACP) that connects sugars together and NADPH converted to NADP to remove oxygen

Question 5

What is Nucleotide anabolism and the 2 types of biosynthesis of it?

Answer 5

Synthesis of pentose sugar;
Pyrimidine Biosynthesis has an Orotic acid precursor and activated ribose is added with a UMP intermediate -> CTP and TMP
Purine Biosynthesis Starts from amino acids, CO2 and formyl groups, Formyl groups added with the help of folic acid Inosinic acid (IMP) intermediate -> AMP and GMP

Question 6

Describe the Inhibitors of Nucleotide Synthesis

Answer 6

Methotrexate, aminopterin inhibits tetrahydrofolate to TMP
6 –mercaptopurine Inhibits conversion of IMP to AMP
5 fluoropyrimidine Blocks conversion on UMP to TMP
Sulfonamides block folic acid synthesis