nucs physics Flashcards

1
Q

band of stability

A

balance of protons and neutrons

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2
Q

alpha decay

A

-release of He (2n + 2p)
-high linear E transfer (heavy, lim range (1 cm/meV)
-not used in img, used in therapy

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3
Q

radioactive decay

A

releasing excess neutrons or protons to reach balance

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4
Q

b-decay: too many neutrons or protons? What’s formed?

A

-too many neutrons
-b-particle, positively charged nuc, anti-neutrino (massless, balance out E)

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5
Q

b-particle

A

negative charge ejected from nucleus during b-decay to form balanced nuc

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6
Q

isobaric transition-what is it, what does it occur with?

A

-no change in mass (because you lost neutron and gained positive charge but they weigh the same)
-occ with b-minus, b-positive (positron emission & electron capture)

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7
Q

how do you block b-emission in a syringe?

A

plastic shield (low Z). if you used high Z (ex: lead) –> bremmmstahlung xray

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8
Q

What sort of b-decay occ with too many protons and not enough neutrons?

A

1) b-positive
2) electron capture

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9
Q

b-positive decay: what does it require?

A

1.02 MeV

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10
Q

what’s formed with b-positive decay?

A

positron + neutrino (worthless POS for balancing E)

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11
Q

what occ with b-positive decay?

A

positron emitted, collides with electron –> two 511 keV photons emitted 180˚ apart from each other

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12
Q

electron capture

A

a nucleus with too many protons steals an electron from inner (K) shell to become neutral

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13
Q

is b-minus decay good for img?

A

No, electron emission can damage DNA (basis of radionuclide therapy)

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14
Q

is e-capture good for img?

A

yes, bc it’s linked to isomeric transition which results in emission of char gamma photon which can be imaged under gamma camera

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15
Q

isomeric transition

A

emission of E (ex: in form of gamma photon) after isobaric transition as a final step to create nuc stability
-mult gamma photons released=mult peaks, ex: Ga67, In-111

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16
Q

what does the m stand for in Tc99m

A

metastable

17
Q

metastable

A

intermediate state after isobaric transition and before isomeric transition

18
Q

3 types of tracer production

A

1) cyclotron (particle zips through vacuum and gains charge)
2) nuclear reactor
3) radionuclide generator

19
Q

Cyclotron-produced radioisotopes

A

molybdenum-99
Fluorine-18
Gallium-67
Thallium-201
*mother fucking gargantuan technique

20
Q

nuclear reactor generation: how does it work

A

fission of 235Uranium –> fission neutrons –> react with 235Ur to create a second fission event –> creates 236Ur –> high E neutron (collide with H2O which slows it down)

21
Q

Reactor produced radioisotopes

A

-Molybdenum 98 (which is then put into cyclotron tomato moly 99)
-iodine 131
-xenon 133
-thal-201

22
Q

generator produce radionuclides

A

-T99m
-Krypton 81m

23
Q

radionuclide purity

A

-how much Mo in Tc
-tested in dose calibrator
-0.15 micro curies of Mo per 1 millicurie of Tc

24
Q

chemical purity

A

-how much Al in Tc?
-tested with pH paper
-<10 micrograms Al per 1 mL Tc

25
Q

radiochemical purity

A

-how much free Tc?
-tested with thin layer chromotography
-95% NaTcO4
-92% sulfur colloid
-91% all other Tc pharmaceuticals

26
Q

transient equilibrium

A

half life of daughter a little shorter than parent
-classic ex: Moly-99 & Tc

27
Q

secular equilibrium

A

half life of daughter way shorter than parent

28
Q

physical half life

A

am of time required for radionuclide to be reduced to half of its existing ac

29
Q

biologic half life

A

how long it takes body to get rid of half the tracer

30
Q

effective half life

A

1/2 physical half life + 1/2 bio half life

31
Q

effective half life

A

1/2 BHL + 1/2 PHL

32
Q

how long do you have to keep radioactive material

A

10 half lives

33
Q

activity

A

am of disintegration per second measure in Becquerel (Bq)=1 disintegration per secdon

34
Q

specific activity

A

activity per unit mass (Bq/g)
*longer the half life, lower its specific act