COMPLEMENT - DEFICIENCY AND ASSOCIATED DISEASE

Question 1

SLE- like syndrome; decrease secondary to a gamma globulinemia

Answer 1

C1q

Question 2

SLE- like syndrome; dermatomyositis, vasculitis, recurrent infections and chronic glomerulo-nephritis, necrotizing skin lesions, arthritis

Answer 2

C1r

Question 3

SLE, SLE-like syndrome

Answer 3

C1s

Question 4

Hereditary angioedema, lupus
nephritis

Answer 4

C1 INH

Question 5

Recurrent pyogenic infections, SLE, SLE-like syndrome,
discoid lupus, membranoproliferative glomerulonephritis, dermatomyositis, synovitis, purpura, Henoch- Schonlein purpura, hypertension, Hodgkin’s disease, chronic lymphocytic leukemia, dermatitis herpetiformis, polymyositis

Answer 5

C2

Question 6

Recurrent pyogenic infections, SLE-like syndrome, arthralgias, skin rash

Answer 6

C3

Question 7

Recurrent pyogenic infections, urticaria

Answer 7

C3 inactivator

Question 8

SLE-like syndrome, SLE, dermatomyositis- like syndrome, vasculitis

Answer 8

C4

Question 9

Neisseria infections, SLE

Answer 9

C5

Question 10

Leiner’s disease, gram-negative skin and bowel infection

Answer 10

C5 dysfunction

Question 11

Neisseria infections, SLE, Raynaud’s phenomenon,
scleroderma-like syndrome, vasculitis

Answer 11

C6

Question 12

Neisseria infections, SLE, Raynaud’s phenomenon, scleroderma-like syndrome, vasculitis

Answer 12

C7

Question 13

Neisseria infections, xeroderma pigmentosa, SLE like syndrome

Answer 13

C8