peptic ulcer disease

Question 1

Prophylaxis vs treatment

Answer 1

prophylaxis: PPIs preferred

treatment: PPIs, histamine blockers, antibiotics
-antacids, H2 blockers, and sucralfate NOT recommended

Question 2

Dif bt H2 blockers and PPIs

Answer 2

H2 neutralize acid; PPIs inhibit its production

Question 3

PPI major risk

Answer 3

pneumonia (and other infections)
*also deplete mg + bone minerals

Question 4

When NOT to use H2

Answer 4

bleeding risk, current GI bleeds, H2 allergies

Question 5

bacteria a/w Peptic ulcers + how to treat

Answer 5

H pylori
treat with 2-3 antibiotics –> diarrhea is side effect

Question 6

Why do NSAIDs cause ulcers?

Answer 6

reduces blood flow, bicarb, and mucus in GI

Question 7

causes of ulcers

Answer 7

H pylori
NSAIDs
alc, stress, smoking
(kinda caffeine, but not really)

Question 8

Antacid role in ulcers

Answer 8

good for prophylaxis, not treatment
Magnesium hydroxide –> diarrhea
Calcium Carbonate –> constipation

don’t affect systemic pH

Question 9

Sucralfate

Answer 9

PPI that creates protective barrier for up to 6 hrs
*active only in acidic environments

Question 10

cimetidine

Answer 10

reacts with CNS meds
H2 blocker

Question 11

eating pattern to avoid ulcers

Answer 11

5-6 small meals –> avoid pH fluctuations

Question 12

Misoprostol

Answer 12

good for ulcers caused by NSAIDS
stimulates secretion of mucus and bicarb

TERATOGENIC

Question 13

Zollinger Ellison syndrome

Answer 13

hypersecretion of acid, causing ulcers