Metabolic Diseases/Disorders

Question 1

What is Lactose Intolerance

Answer 1

Lactose is too big to pass through digestive tract lining
- must be broken down into galactose and glucose by lactase
- there is underproduced lactase
- lactose remains in the GI tract and ferments

symptoms = farting, diarrhoea, cramps, bloating

Question 2

What is Galactosemia?

Answer 2

inherited autosomal recessive disorder of a deficiency of galactose-1-phosphate uridyl transferase

• can be screened for at birth
• if its not active in the eye
• aldose reductase reduces galactose into galactitol
  = cataracts in the eye

symptoms = enlargement of liver, CNS failure

Question 3

How do you Prevent Caries Undergoing Glycolysis?

Answer 3

fluoride
- inhibits enolase