Rhabdoviruses Flashcards
Genome type
(-)ssRNA
capsid type
helical
enveloped?
enveloped
segmented?
nonsegmented
What is absolutely required to be packaged for full replication?
Must include Large polymerase (L) and phosphoprotein (P) for primary transcription since (-)ssRNA
VAP (VSV and Rabies)
Glycoprotein (G)
Nucleoprotein (N)
coats the genome
What’s required for primary transcription?
Large polymerase (L) and phosphoprotein (P)
Matrix (M)
connects the nucleocapsid to the membrane
What is the representative virus?
Vesicular Stomatitis Virus (VSV)
Host receptor for VSV
LDL-R
Does the VAP do fusion too?
Yes, G protein also does fusion
Host receptor for rabies
G protein binds Nicotinic Acetylcholine Receptor (NAR) on neurons
How does the host receptor confer a wide host range for rabies?
Extremely large host range because acetylcholine is an essential neurotransmitter in many organisms so NAR is very conserved
What’s weird about plant rhabdoviruses?
They are enveloped and get it from inner organelle membranes