M7 - Pentose Phosphate Shunt

Question 1

___ cells express the pentose phosphate shunt

Answer 1

ALL

Question 2

Branchpoint intermediate can =

Answer 2

= ribose 5 P
or
= re-enter glycolysis

Question 3

The first and rate-limiting enzyme of the pentose shunt is _____, which generates one of the NADPH molecules

Answer 3

glucose-6-phosphate dehydrogenase (G6PD)

Question 4

NADPH Functions

Answer 4

1. Lipid synthesis, e.g.:
   a. Fatty acids (FA)
   b. Cholesterol (C)
   c. Steroid hormones
   d. Bile acids
2. Maintains gluta- thione in a reduced form (“GSH”) to act as an anti-oxidant

Question 5

Ribose-5-P Function

Answer 5

Nucleotide synthesis

Question 6

All cells EXCEPT ____ synthesize RNA and DNA in their nuclei

Answer 6

RBCs

Question 7

All cells use ____ to maintain glutathione as an anti-oxidant

Answer 7

NADPH

Question 8

Pentose shunt generates most of the ____ needed to maintain GSH for the rest of cell

Answer 8

NADPH

Question 9

____ require NADPH from pentose shunt to prevent excessive hemolysis (and anemia)

Answer 9

RBCs