ibuprofen

Question 1

Classification

ibuprofen

Answer 1

• Analgesic
• Antipyretic
• NSAID

Question 2

Brand Names

ibuprofen

Answer 2

Advil
Motrin
Actiprofen

Question 3

INDICATIONs

ibuprofen

Answer 3

[EMR]
- mild to moderate pain

[ACP]
- mild to moderate pain
- pyrexia

Question 4

CONTRAINDICATIONs

ibuprofen

Answer 4

• HYPERSENSITIVITY
• active GI bleed
• pregnancy

Question 5

Dosage - ADULT

ibuprofen

Answer 5

[EMR]
300-400mg - P

repeat 4-6hrs
MAX - 1200mg/day

Question 6

Dosage - PEDATRIC

ibuprofen

Answer 6

[PCP]
10mg/kg

repeat x 1 @ 6hrs

MAX dose - 40mg/kg/day

Question 7

Pharmacodynamics

ibuprofen

Answer 7

inhibits prostaglandin synthesis =
- decreased pain
- decreased inflammation
- decreased pyrexia

Question 8

Pharmacokinetics

ibuprofen

Answer 8

ORAL - analgesic
onset - 30-60mins
peak - 1-2hrs
duration - 4-6hrs

ORAL - antipyretic
onset - 30min-2.5hrs
peak - 2-4hrs
duration - 6-8hrs

Question 9

ADVERSE EFFECTs

ibuprofen

Answer 9

• unlikely after single pre-hospital dose, however note NSAIDs use hx
• GI upset > ulcer > bleeding > perforation

Question 10

OVERDOSE

ibuprofen

Answer 10

• GI irritation
• CNS depression

tx - primarily supportive

Question 11

Warnings // Precautions

ibuprofen

Answer 11

consider ALTERNATIVE TX for pt w/
- GI problems
- RENAL dysfunction
- significant CVS hx

NSAIDS have the potential to cause significant adverse reactions - the RISK increases w/ dose, therapy and underlying risk factors

Question 12

DRUG INTERACTIONs

ibuprofen

Answer 12

NSAID may increase BP, limiting effects of ANTI-HYPERTENSIVES