acetylsalicylic acid [Aspirin]

Question 1

Classification

ASA

Answer 1

• Antiplatelet
• Antithrombotic
• NSAID
• Antipyretic

Question 2

Pharmacodynamic

ASA

Answer 2

Inhibits the formation of thromboxane A2 which is a potent platelet aggregate and vasoconstrictor

• antiplatelet effects are IRREVERSIBLE - lasts for the life of platelets ~7-10 days

Question 3

Pharmacokinetics

ASA

Answer 3

ORAL
onset - 5-30mins
peak - 1 to 2hrs
duration - 4-6 hrs

Question 4

INDICATIONs

ASA

Answer 4

[EMR]
- Chest pain // signs & symptoms consistent with CARDIAC ISCHEMIA // ?AMI

Question 5

CONTRAINDICATIONs

ASA

Answer 5

• HYPERSENSITIVITY (to ASA or other NSAIDs)
• hx bronchospasm/other respiratory distress precipitated by ASA//NSAIDs
• ACTIVE//recent bleeding of any kind - head injury, stroke, peptic ulcer disease
• PEDIACTRICs presenting with viral symptoms consistent w/ REYS’S SYNDROME

Question 6

Warnings // Precautions

ASA

Answer 6

• should NOT be used in PEDIATRICs/young adults w/ - chicken pox, influenza, or ILI — RISK of developing REYE’s SYNDROME
• ETOH use = increase RISK for GI bleeding

REYE’s SYNDROME - encephalopathy, acute liver damage

Question 7

Dosage - ADULT

ASA

Answer 7

162mg - PO

chewed & swallowed

Question 8

ADVERSE EFFECTS

ASA

Answer 8

• Irritation of the GI tract - COMMON
• anti-platelet effect > minor bruising/bleeding

Question 9

OVERDOSE

ASA

Answer 9

TOXICITY @ doses
>150mg/kg

• 150lbs/68kg ~10.2g = ~126 tabs @81mg

symptoms:
- NVD
- diaphoresis
- tinnitus
- hyperventilation

Question 10

DRUG INTERACTIONs

ASA

Answer 10

• anti-coagulants = cliniCALL for RISK vs BENEFITS of pt experiencing cardiac ischemia