developing pain

Question 1

sensory fibres

Answer 1

A-beta : large myelinated; touch, pressure & vibration

A-delta: small myelinated; cold, fast pain, sharp

C: unmyelinated; warmth, slow pain, dull, diffuse

Question 2

peripheral sentisisatoin

Answer 2

chemical mediators - macrophages, neutrophils, mast cells - release chemicals - PGE2, bradykinin, adrenaline which stimulate different receptors on nociceptive terminal , allow ions to move into nerve
also NGF binds to TrkA and stimulates expression of new receptors

threshold for depot lowered - small stimulus will result in activation