13.2: Drugs Affecting Gut Motility Flashcards Preview

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Flashcards in 13.2: Drugs Affecting Gut Motility Deck (20):
1

How does domperidone exert its anti emetic function?

D2 antagonism, by acting centrally on the postrema of the 4th ventricle, and locally on the stomach to increase the rate of gastric emptying

2

What is the 1st line anti emetic drug?

Metclopramide

3

How does metclopramide exert its anti emetic function?

D2 antagonism (increasing gastric emptying and acts centrally on the 4th ventricle)

4

What are some side effects of D2 antagonist anti emetics?

Galactorrhea
Dystonia (rare)
Beware in Parkinson’s

5

What anti emetic is used for motion sickness and how does it work?

Hyoscine
Antagonises muscarinic cholinergic receptors

6

Which anti emetic is 2nd line?

Cyclisine

7

How does the anti emetic cyclisine act?

H1 antagonist

8

What are conservative methods to manage constipation?

Increase fluid intake
Increase fibre intake
Do more exercise

9

What are some drugs that can cause constipation?

Opioids
Anticholinergics
Antidepressants
Iron

10

What type of laxative is senna?

Stimulant laxative which increases intestinal motility

11

What electrolyte abnormality can repeated use of Senna lead to?

Hypokalaemia

12

How do bulk laxatives work?

They are insoluble substances that bulk up the stool and lead to gut distension which activates stretch receptors to stimulate peristalsis

13

Which enema is indicated for rapid bowel evacuation?

Phosphate enemas

14

How do phosphate enemas act?

Cause water retention in the small and large bowel which stimulates rapid peristalsis and bowel evacuation

15

What is Imodium used for?

Diarrhoea

16

What receptors in the bowel does Imodium act on?

Opioid receptors

17

How does Imodium work?

Acts on opioid receptors to reduce bowel motility so there is more time for fluid to be reabsorbed
Also reduces anal tone

18

Which type of anti diarrhoea drug can be used for IBS?

A bulk forming e.g. ispaghula

19

What type of laxative should be used if the faeces is soft?

Stimulant laxative e.g. senna

20

What type of laxative should be used if the faeces is hard?

Osmotic laxative
Bulking forming laxative