15k. Men's Health - Prostate Cancer & Prostatitis Flashcards

1
Q

Signs and symptoms of prostate cancer

A

Same as BPH +
Haematuria
Pain on ejaculation
Back pain

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2
Q

Risk factors for prostate cancer

A

Dietary
Abdominal obesity
Poor methylation
Increased 5a-reductase
Dysbiosis
Nutrient def/insufficiencies
SNPs

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3
Q

What dietary factors can contribute to prostate cancer?

A

Processed meats
High refined sugar
Low fibre
Caffeine
High saturated/trans fats
Dairy

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4
Q

What causes of abdominal obesity can lead to prostate cancer?

A

Increased insulin resistance
Chronic inflammation
Dysregulated sex hormones

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5
Q

How might poor methylation come about?

A

Lack of key nutrients
COMT SNP
Low AO status

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6
Q

How might dysbiosis contribute to prostate cancer?

A

Dysbiosis can raise beta-glucuronidase = raised circulating oestrogens = cell proliferation
Impaired barrier = low grade inflammation

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7
Q

Which SNP could contribute to prostate cancer?

A

CYP3A4

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8
Q

Why can a SNP on CYP3A4 contribute to prostate cancer?

A

Associated with oxidative deactivation of testosterone

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9
Q

Natural approach to prostate cancer

A

Naturopathic diet with focus on Zn and Se-rich foods
Med diet

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10
Q

Nutrients to support prostate cancer

A

Se
Zn
D
Lycopene
Reishi
Shiitake

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11
Q

Why is Se good for prostate cancer?

A

Increases glutathione peroxidase

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12
Q

Dosage of Se to support prostate cancer

A

200-600mg/day

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13
Q

Why is Zn good for prostate cancer?

A

Inhibits prostate cancer cell growth

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14
Q

Dosage of Zn to support prostate cancer

A

15-30mg/day

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15
Q

Which nutrients can increase intestinal and prostate absorption rates?

A

Quercetin
Resveratrol
EGCG
Curcumin

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16
Q

Why is vit D good for prostate cancer?

A

Anti-proliferative

17
Q

Why is lycopene good for prostate cancer?

A

Induces apoptosis
Blocks cellular gap junction responsible for cancer cell invasion

18
Q

Dosage of lycopene for prostate cancer

A

2tbsp tomato puree/day

19
Q

Why is reishi good for prostate cancer?

A

Triterpenes suppress migration and invasion of prostate cancer cells
Induces apoptosis

20
Q

Dosage of reishi to support prostate cancer

A

3-9g/day

21
Q

Why is shiitake good for prostate cancer?

A

Anti-proliferative
Anti-angiogenic
(due to beta glucan lentinan)

22
Q

Dosage of shiitake to support prostate cancer

A

1.5-10g/day

23
Q

Signs and symptoms of prostatitis

A

Similar to BPH+
Frequent UTIs
Dysuria
Blood in urine or semen
Urethral discharge
Pain on ejaculation
Pain around genitalia/anus/lower abdomen

24
Q

Causes of prostatitis

A

Chronic low-grade inflammation
Low immune function
Low testosterone
Genitourinary dysbiosis
STDs

25
Q

Natural approach to prostatitis

A

Naturopathic diet with focus on lowering inflammation
Supporting immune system
Zn/Se/Lycopene/Saw palmetto - prostate support
Quercetin - to reduce inflammation
Pro-/prebiotics to increase microbial diversity