Neuromuscular Junction Workshop Flashcards
Cocentration reponse curve
with an increase in the concentration of carbachol there is an increase in physiological range
the relationship between concentration and response in a linear plot
the relationship between concentration and response is hyperbolic
What is EC50
EC50 is the concentration of agonist that elicits a half maximal reponse
Why is linear plot is not used
the reason linear plot is not used as it is hard to read the EC50 accurately
semi logarithmic plot
The semi logarithmic plot relationship between concentration and response is sigmodial
What does the presence of an antagonist cause to the graph
In the presence of an antagonist, the agonist concentration-response curve is ‘shifted to the right’ without a change in maximal response or change in slope (i.e., the ‘shape’ of the concentration response curve remains unchanged)
what does the antagonist action described as
the antagonist action of atropine is surmountable over a range of carbachol (agonist) concentration
what does the competitive antagonsit cause
Non-competitive antagonists depress the slope and maximum of the concentration response curve, but do not cause a rightward shift
antonist progressive cocentration
antagonistProgressive rightward shift of agonist concentration response curve on concentration axis but no depression of slope
Non competitive inhibition
Progressive depression of maximum response and slope, but no shift of agonist concentration response curve on the concentration axis
what is IC50
IC50 is the concentration of an antagonist where the agonist evoked a response is reduced by 50%
