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BPK 336 - Histology > Lecture 5 - Connective Tissue Proper > Flashcards

Lecture 5 - Connective Tissue Proper Flashcards

1
Q

def: a matrix that links and supports other tissue types

A

connective tissue

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2
Q

what are the 2 main functions of connective tissue?

A
  1. structural support and organization
  2. metabolic support and transit
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3
Q

by volume, what does connective tissue consist of :

A
  1. few resident cells that are embedded in ECM
  2. protein fibers (collagen and elastin), ground substance
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4
Q

what are the 3 types of protein fibers in ECM?

A
  1. elastic fiber
  2. collagen fiber
  3. reticular fiber
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5
Q

def: more fibers, less ground substance, fewer cells

A

dense CT

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6
Q

def: few fibers, more ground substance, more cells (greater variety of cells)

A

loose (areolar) cells

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7
Q

def: found predictably in CT in stable numbers

A

fixed cells

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8
Q

def: enter connective tissue in response to a cue (infection or injury)

A

wandering/transient cells

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9
Q

def: immature cells, high division potential, multiple phenotypic fates, often produce and maintain ECM

A

-blasts

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10
Q

def: mature cells, lower division potential and more determined phenotypic fates

A

-cytes

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11
Q

def: often prune/remodel the ECM

A

-clasts

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12
Q

def: most numerous and critical cellular component of connective tissue, very common in loose CT and only cell of dense CT, large nuclei, abundant rER, surrounded by collagen

A

fibroblasts

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13
Q

def: synthesize collagen, elastic fibres, most carbohydrates of the ground substance, and reticulin

A

fibroblasts

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14
Q

what are fibroblasts nuclei like?

A

elongated, elliptical nuclei

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15
Q

what are fibroblast characteristics on EM?

A
  • euchromatic nucleus
  • prominent nucleolus
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16
Q

how are fibroblasts activated?

A
  • by injury
  • build basement membrane and sense tension
17
Q

def: most abundant protein in the human body

A

collagen

18
Q

def: type of collagen responsible for skin, tendon, vasculature, organs, bone

A

Type I

19
Q

def: type of collagen responsible for cartilage

A

Type II

20
Q

def: type of collagen responsible for reticulin, commonly found alongside Type I

A

Type III

21
Q

what type of collage in the majority of collagen in the body?

A

Type 1, 90%

22
Q

def: heterogenous group of inherited connective tissue disorders characterized by joint hyper mobility, cutaneous fragility, and hyperexternsibility

A

elhers-danlos sysndrome

23
Q

def: CT in skin, aponeurotic fascia, tendons, ligaments, collagen fires are oriented in one direction and tightly packed, for maximum tensile strength

A

dense, regular connective tissue

24
Q

def: modified dense CT that contains substantial amounts of elastin

A

elastin CT

25
Q

def: fibres that stretch under tension but produce recoil, prominent in large arteries

A

elastin

26
Q

is elastin eosinophilic or basophilic?

A

eosinophilic, wave like confomration

27
Q

def: contains bundles of collagen fibers that are more randomly interwoven, with no definite orientation

A

dense, irregular connective tissue

28
Q

what is the difference between dense irregular and regular CT in terms of how they provide resistance to stress?

A

regular = single axis
irregular = all directions

29
Q

where is DICT found?

A

dermis layer of the skin and capsules surrounding most organs

30
Q

def: delicate and contains cells, fibers, and ground substance equally

A

loose connective tissue (areolar)

31
Q

fibroadipose tissue can be found in the _________

A

finger, but most common type of CT in the body

32
Q

def: modified loose CT, characterized by delicate matrix of type III collagen (reticulin)

A

reticular CT

33
Q

where is reticular CT found?

A

support structure in many organs: endocrine glands, lymph nodes, bone marrow, liver, reticular lamina of BMs

BPK 336 - Histology (12 decks)

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