Lecture 5 Flashcards
When you breathe in cold air what does the sinuses do?
Regulates the coldness and humidity to match what’s in your body
What is the role of turbinates?
Help regulate the air and humidity as it passes through your nasal cavity
What do goblet cells produce?
Mucus
Define drug deposition
Where the drug is deposited in the nasal cavity
Define mucosal absorption
How the drug is absorbed across the mucosa
Define mucocilliary clearance
The movement of mucus layer to the nasopharynx
What three properties affect how quickly a particle passes through nasal cavity?
Temperature, anatomy, and nasal clearance
How often does mucus clear towards the nasopharynx?
10-20 mins
Where do particles land?
Ciliated regions, non-ciliated regions, nasopharynx
What are the drug formulation requirements?
Even distribution in the nasal cavity, ensure it does not impact ciliary action negatively
What does the mucus layer consist of?
Mainly water, some salts, lipids and proteins
How can drug permeability be improved?
Permeation enhancers, control drug delivery systems, colloidal drug carriers
opening of tight junctions between adjacent cells for improved paracellular diffusion
change of lipid bilayer integrity and membrane fluidity promoting trans cellular permeation of drugs
How to reduce mucociliary clearance?
Increasing viscosity
Adding polymers
Using gel formulations
Improve retention time of drugs
