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CPT Drugs > Neurological disorder drugs > Flashcards

Neurological disorder drugs Flashcards

1
Q

Levodopa - ADRs?

A

Dopamine receptor agonist

Dopamine cannot cross BBB

Nausea/anorexia
Hypotension
Psychosis

High protein meals compete across BBB
Vit B6 - ^peripheral breakdown of levodopa

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2
Q

Co-careldopa

A

Levodopa + peripheral dopa decarboxylase inhibitor

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3
Q

Entacapone

A

COMT inhibitor

Reduces peripheral breakdown of levodopa

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4
Q

Selegiline, Rasagaline

A

Monoamine Oxidase B inhibitor

Prevents dopamine metabolism

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5
Q

Ropinirole

A

Dopamine receptor agonist

Add on therapy

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6
Q

Orphrenadine, Procyclidine

A

Anticholinergic

Inhibits Ach (for problematic tremor)

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7
Q

Acetylcholinesterase Inhibitors - ADR?

A

Pyridostigmine (oral)
Neostigmine

Stops breakdown of Ach

Sweating
Salivation
Lacrimation
Urinary incontinence
Diarrhoea
GI upset
Emesis

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8
Q

What drugs should you caution prescribing as they worsen myasthenia gravis?

A

ACE-i
B blockers
CCB

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9
Q

Which anti-emetic should you not give to a patient with parkinson’s?

A

Metoclopramide (D2 antagonist)

Domperidone acts on A2 but doesn’t cross BBB

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CPT Drugs (19 decks)

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