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ORGMED —> ANTIFUNGALS > Antimicrobials 3-4 > Flashcards

Antimicrobials 3-4 Flashcards

1
Q

Old Cephalosporins

A

Cephalosporium acremonium

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2
Q

Nucleus of cephalosporin:

A

7-aminocephalosporanic acid (7-ACA)

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3
Q
  • excellent agents for skin and soft tissue infections due to S. aureus and S. pyogenes
A

1st generation

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4
Q

• more resistant to B-lactamases and better acid stability

A

Cephalosporin

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5
Q
  • DOC for many G(-) bacteria
  • parenterally
A

3rd generation

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6
Q

used for UTI in pregnant women

A

Cefalexin

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7
Q

new DOC for typhoid fever

A

Ceftriaxone

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8
Q

for the treatment of community -acquired pneumonia (CAP)

A

Cefotaxime, Ceftriaxone

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9
Q
  • used for the treatment of nosocomial infections
A

4th generation

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10
Q
  • broad spectrum for multidrug-resistant bacteria, including P. aeruginosa
A

Carbapenems

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11
Q

B-lactamase-resistant but is deactivated by renal dehydropeptidase-I (DHP)

A

Imipenem

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12
Q

inhibits impenem degradation by dehydropeptidase

A

Addtion of Cilastatin

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13
Q

active against MRSA and Pseudomonas

A

5th Generation

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14
Q

greateractivityagainstG(+)cocci, Enterobacter, and Pseudomonas

A

4th generation

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15
Q

What are the antipseudomonal cephalosporins (useful for pseudomonads):

A

Cefoperazone, Cefotaxime, Ceftazidime, Ceftriaxone, Moxalactam

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16
Q

be used to treat respiratory tract infections in IV form

A

Cefuroxime

17
Q

can be used to treat respiratory tract infections in PO form

A

Cefuroxime axetil

18
Q
  • from Streptomyces cattleya
A

Thienamycin

19
Q

contributes to high protein binding and prolongs
the half-life of the drug in ertapenem

A

benzoic acid

20
Q

+ Cilastatin: inhibits impenem degradation by dehydropeptidase. Under what brand name

A

Tienam®

21
Q

inactive against G(+ and with moderate activity against a narrow group of G(-) bacteria, including P. aeruginosa

A

Monobactam

22
Q

therapeutically equivalent to impenem

A

Meropenem

23
Q

isolated from Chromobacterium violaceum

A

Aztreonam

24
Q

Also know as “Suicide Drugs”

A

B-Lactamase Inhibitors

25
Q

with very little to no antibacterial activity

A

B-Lactamase Inhibitors

26
Q

+piperacillin

A

Tazobactam

27
Q

Piperacillin + Tazobactam brand names

A

Tazocin®, Piptaz®, Zosyn®

28
Q
  • from Streptomyces clavuligerus
A

Clavulanic acid

29
Q

Sulbactam + ampicillin brand name

A

Unasyn ®

30
Q

Clavulanic acid + amoxicillin =

A

Co-amoxiclav

31
Q

Co-amoxiclav brand name

A

Augmentin®

32
Q
  • irreversibly bind to and inactivate B-lactamase or penicillinase
A

B-Lactamase Inhibitors

33
Q

Clavulanic acid + ticarcillin brand name

A

Timentin®

34
Q

What are the suicide drugs

A

Clavulanic acid
Sulbactam
Tazobactam

35
Q

Carbapenems drugs

A

Thienamycin
Meropenem
Imipenem
Ertapenem

36
Q

the first cephalosporin

A

Cephalosporin C

ORGMED —> ANTIFUNGALS (7 decks)

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