Immuno 11: Hypersensitivity

Question 1

Type 1 hypersensitivity

Answer 1

allergy caused by IgE mast cell activation

Question 2

Type 2 hypersensitivity

Answer 2

Antibodies directed against cells or tissues, impairing function

Question 3

Type 3 hypersensitivity

Answer 3

Antibodies against soluble antigens form complexes and deposit in blood vessels, causing inflamation and tissue injury

Question 4

Type 4 hypersensitivity

Answer 4

T lymphocytes specific for self antigens attack tissues

Question 5

Atopy

Answer 5

synonym for allergy

Question 6

Sequence of events in development of immediate hypersensitivity reactions

Answer 6

Activation of Th2/IL-4helper t cells in response to antigen

Production of IgE by Th2/IL-4

IgE binds to mast cells leading to activation

Question 7

Late-phase reaction

Answer 7

Part of mast cell activation. Comes from neutrophil and eosinophil recruitment. Repeated bouts can cause tissue injury

Question 8

IL-4 secreted by ____ stimulates _____ to switch to IgE producing plasma cells

Answer 8

IL-4 secreted by Tfh cells stimulates B lymphocytes to switch to IgE producing plasma cells

Question 9

Histamine function

Answer 9

Increased vascular permeability, vasodilation, contraction of smooth muscle

Question 10

Arachidonic acid metabolites are released by

Answer 10

Mast cells

Question 11

Arachidonic acid metabolites include

Answer 11

Prostaglandins and leukotrienes

Question 12

Proteases released by mast cells cause

Answer 12

Tissue damage

Question 13

Cytokines produced by mast cells stimulate the recruitment of_______, which cause the _________.

Answer 13

Cytokines produced by mast cells stimulate the recruitment of leukocytes, which cause the late-phase reaction.

Question 14

Hay fever

Answer 14

Allergic rhinitis and sinusitis caused by pollen

Question 15

Most common cause of asthma

Answer 15

Respiratory allergy in which inhaled allergens stimulate bronchial mast cells to release mediators like leukotrines which cause bronchial constriction

Question 16

What class of Ig causes type 2 hypersensitivity

Answer 16

IgG

Question 17

Glomerulonephritis hypersensitivity type

Answer 17

3

Question 18

Cross reaction hypersensitivity type

Answer 18

Type 2

Question 19

Therapy for type 2 hypersensitivity reactions

Answer 19

Limiting of imflammation with drugs like corticosteroids

Question 20

Arthus reaction

Answer 20

Subcutaneous adminstration of protein antigen to previously immunized animal results in formation of immune complexes at site of antigen injection

type 3 hypersensitivity

Question 21

Hypersensitivity reaction limited to a tissue type

Answer 21

type 4

Question 22

Delayed type hypersensitivity AKA

Answer 22

Type 4

Question 23

Therapy for t cell hypersensitivity

Answer 23

Reduce inflammation and inhibit t cell response