Tanslocation Flashcards
What in the endothelium filters large MW molecules
Protein matrix in between cells
How can drugs cross membranes
Diffusing direct through lipid
Through aqueous pores
Carrier protein
Pinocytosis (macromolecules)
How can drug diffuse through lipid
Non polar are permeable
Ratio of charged / uncharged drug is determined by …
pH of compartment
The lipid solubility of uncharged drugs depends on …
Chemical nature of drug
Aspirin has a PKA of …. And is ionisated in
3.5
Alkaline pH
What does increasing plasma pH do
Charges weak acids
What is excreted as a result of urinary acidification
Weak bases
What is excreted as a result of urinary alkalisation
Weak acids
In the proximal tubule what caused excretion of aspirin
Urinary alkalisation
-salicylate is charged so much less is reabsorbed
Why is cisplatin nephrotoxic
It is taken up efficiently into proximal tubule by OCT23
Rate of secretion is lower
Causes destruction of mitochondria
