Factord Affecting Metabolism Flashcards
Name some factors affecting metabolism
Age
Species
Strain
Hormones liver disease
Effects of being elderly
Not necessarily linked to CYPs
Liver decreases in mass
Effects in neonates
CYPs are low
Lack of bilirubin glucuronidarion causes build up of bilirubin - Brian damage
Chloramphenicol causes grey baby syndrome
What is no longer used do to rat and dog toxicity
Coumarin
What conjugation occurs more in animals that man
Glucuronidation
What conjugation occurs more in man than animals
Sulphation
What is doffeeemt in different rat strains
AhR expression
Female DA rat lacks rat equivalent of CYP2D6
What CYP does growth hormone affect
CYP2C isoforms
Which rats have continuous levels of GH and what does this induce expression of
Female rats
CYP2C7 & CYP2C12
Which rats have intermittent levels of GH and what does this induce expression of
Male rats
CYP2C11 & CYP2C22
What liver disease affect metabolism
Ethanol poisoning
Cirrhosis
Porphyria
Explain alcoholic reaction to paracetamol
Alcoholics that are sober can experience paracetamol induced liver toxicity and half the dose of normal people
Who should avoid drinking alcohol
Tuberculosis patients taking isoniazid - disulphiram reaction
What does cirrhosis do to metabolism
Reduction of blood flow to liver
Major increases in bioavailability
What does porphyria do to metabolism
Impaired synthesis of haem & accumulation of toxic precursors
P450 levels lower
