S1_L4: Cell Signaling and Communication Flashcards
Determine the corresponding descriptions of the general types of intercellular communication
- Common & through the paracrine and nervous system
- Direct cell to cell communication
- Important in immune responses
A. Membrane bound signaling
B. Gap junction
C. Chemical signaling
- C
- B
- A
It receives a particular chemical which will
attach to the receptor and will be able to open the gate. It has the capacity to close and open; like a lock and key receptor.
Receptor / Ion Channel / Primary Ligand-Gated Receptor
TRUE OR FALSE: The receptor is both the effector and ion channel. This means that once the chemical arrives the channel can now immediately open and does not need a separate
protein.
True
A multi-ion channel ligand and voltage-gated glutamate receptor that is involved in memory. It allows both sodium and calcium to enter and
potassium to exit.
N-Methyl D-Aspartate Receptor (NMDA)
A chloride channel that responds to Gamma Amino Butilic Acid. Once GABA binds, the receptors will open and chloride can now enter the cell.
GABA Receptor-Cl- channels
Once glycine arrives at this ligand-gated channel, chloride can now enter
Glycine Receptor-Cl- channels
These receptors are coupled to intracellular surface G proteins that initiate intracellular signal transduction
G Protein-linked receptors
Determine the corresponding descriptions of the G protein-linked receptor types
- adenylate cyclase to produce AMP
- K+ ion channel-linked in CNS
- activates Phospholipase C = IP3 and DAG
- inhibits adenylate cyclase
- converts light to electrical signals
- K+ ion channel-linked in heart
A. Gi
B. Gk
C. Go
D. Gp
E. Gs
F. Gt
- E
- C
- D
- A
- F
- B
Once Ach and nicotine binds to this channel-linked receptor, it will open and the sodium ions will enter the cell and allows potassium to exit. The response of the target cell is its gate opens and depolarization happens, an influx of sodium and efflux of potassium occurs.
Nicotinic Ach-Na+ channels
Enumerate the 4 signal transduction occurring at the cell surface
- Receptor/ion channel
- Catalytic receptors
- G protein-linked receptors
- Cytokine
A substance must be ___ soluble to be able to transduce a signal at the cell interior.
Lipid
Determine the corresponding descriptions of the types of cell signaling
- Local release to nearby cells
- Neurons release chemical signals into circulation
- Substance travels long distances via circulation
- Via gap junctions, cells do not traverse the ECF
- Release of neurotransmitter at terminal
A. Direct communication
B. Paracrine signaling
C. Endocrine system
D. Nerve conduction
E. Neuroendocrine
- B
- E
- C
- A
- D
Determine the corresponding descriptions of the types of cell signaling
- Exocytose the message, received by nearby
target cell - Autocrine signaling
- Example is sympathetic nervous system
- Bloodstream acts as a highway for this signaling
- special type of paracrine signaling that is within the nervous system
A. Direct communication
B. Paracrine signaling
C. Endocrine system
D. Nerve conduction
E. Neuroendocrine
- B
- B
- E
- C
- D
What is the term for when the cell stimulates
itself? This is present in the immune system
Autocrine signaling
In the G protein-linked receptors, what is the ligand that increases our heart rate and bind to a receptor that is sensitive to it, shake the G-protein to the point that the alpha
subunit will be dislodged and it will attach to the enzyme, adenylate cyclase?
Norepinephrine
