Sjogren's syndrome

Question 1

Sjogren’s syndrome is an autoimmune disorder affecting what?

Answer 1

Exocrine glands

Question 2

Name a condition Sjogren’s syndrome can occur secondary to

Answer 2

SLE, RA

Question 3

With Sjogren’s syndrome, there’s a marked increase of what malignancy?

Answer 3

Lymphoid malignancy

Question 4

Is Sjogren’s syndrome commoner in males or females?

Answer 4

Females (9:1)

Question 5

Name a feature of Sjogren’s syndrome

Answer 5

• Dry eyes
• Dry mouth
• Arthralgia
• Dry vagina
• Raynaud’s
• Myalgia
• Sensory polyneuropathy
• Recurrent episodes of parotitis

Question 6

1) Which antibody is present in nearly 50% of patients?
2) Which 2 antibodies are present in around 70% of cases?
3) Which antibody is present in around 30% of patients?

Answer 6

1) RF
2) Anti Ro and ANA
3) Anti La

Question 7

What is Schirmer’s test?

Answer 7

Filter paper placed near the conjunctival sac to measure tear formation

Question 8

Name a feature of Sjogren’s syndrome that may be seen on histology

Answer 8

• Hypogammaglobulinemia
• Low C4
• Focal lymphocytic infiltration

Question 9

Name an option for the management of Sjogren’s syndrome

Answer 9

• Artificial saliva and tears
• Pilocarpine may stimulate saliva formation