CYTOKINES AND INTERLEUKINS

Question 1

Interleukin 1 are released by ?

Answer 1

Macrophages

Question 2

Interleukin 1 causes what?

Answer 2

Acute phase response
Fever
Hypotension
Tacycardia

Question 3

Interleukin 2 role?

Answer 3

Released by TH cells
For growth and differentiation of T cells

Question 4

IL3 role?

Answer 4

Released by activated Th1 cells
Differentiation and proliferation of myeloid progenitors

Question 5

Interleukin 4

Answer 5

Released by macrophages and TH cells

Stimulates differentiation of B cells

Question 6

Role of interleukin 8 ?

Answer 6

Released by macrophages
And Causes chemotaxis of neutrophils

Question 7

Role of IL10

Answer 7

Produced by TH2
Inhibits TH1 cytokine - anti inflammatory cytokines

Question 8

Role of IL12

Answer 8

Produced by dendritic cells
Macrophages and B cells

Stimulates differentiation of immature T cells into TH1 cells

Question 9

Interferon gamma?

Answer 9

Released by Th1 cells and natural killer cells -ACTIVATES MACROPHAGES

Question 10

Interferon beta produced by and action

Answer 10

produced by fibroblasts
antiviral action

Question 11

Use of interferon B

Answer 11

reduces the frequency of exacerbations in patients with relapsing-remitting MS

Question 12

Interferon alpha produced by and action?

Answer 12

produced by leucocytes

antiviral action

Question 13

Interferon alpha use ?

Answer 13

useful in hepatitis B & C, Kaposi’s sarcoma, metastatic renal cell cancer, hairy cell leukaemia

Question 14

Receptors for interferon ?

Answer 14

IFN-alpha and IFN-beta bind to type 1 receptors whilst IFN-gamma binds only to type 2 receptors.

Question 15

interferon-alpha side effects ?

Answer 15

flu-like symptoms and depression