Hemoglobin RS

Question 1

The heme pocket of what polypeptide chain is large enough to occupy the O2?

Answer 1

Alpha chain

Question 2

The heme pocket of the beta chain is blocked by?

Answer 2

Valine residue

Question 3

At what carbon position of heme does it bond with the Arginine and lysine of the polypeptide chain?
List in respective order

Answer 3

Carbon 6- Arginine
Carbon 7- lysine

Question 4

The polypeptide chain of globin contains numerous amino acids such as?

Answer 4

Histidine
Isoleucine
Lysine

Question 5

The 5th linkage of Fe ( internal linkage) is between the Fe and …………. Ring of histidine in the polypeptide chain

Answer 5

Imidazole ring

Question 6

Hb A3 is an altered form of HbA discuss

Answer 6

Hb A3 is an electrophoretically fast fraction of HbA.
It is found in old RBCs.
Amounts3-10%

Question 7

HbA1c is a form of the glycosylated form of Hb A discuss

Answer 7

It is found in a ℅3-5 % of total Hb
It can increase to up to 6-15% in Patients with diabetes mellitus