Microsomal Induction

Question 1

List the 5 drugs that induces hepatic microsomal entymes

Answer 1

RAG So Long
R- Rifampicin
A- Anticonvulsants
G- Griseofulvin
S- Spironolactone
L- long term alcohol abuse

Question 2

List the examples of anticonvulsants

Answer 2

PPPC
Phenobarbitone
Phenytoin
Primidone
Carbamazepine

Question 3

Drugs that are metabolized include

Answer 3

Benzypyrene, Aminopyrene, aniline, morphine, benzphetamine.
BBAAM

Question 4

P450 enzyme stabilization can be induced by ……

Answer 4

Clotrimazole-mediated induction CYP3A
Ethanol-mediated induction of CYP2E1

Question 5

What is the most important circulating protein for drug binding in plasma

Answer 5

Albumin, alpa1 acidic glycoprotein and lipoprotein.

Question 6

Basic drugs bind mainly to…..

Answer 6

Albumin

Question 7

Basic drugs bind to

Answer 7

Albumin alpha 1acid glycoprotein and lipoprotein

Question 8

The half-life of a drug can be equated to ……

Answer 8

The time it takes for microsomal enzymes to detoxify the medicinal drugs

Question 9

How many families of microsomal enzymes are coded for

Answer 9

14-16 families

Question 10

Another name for cytochrome p450 is ?

Answer 10

Mixed oxygenases

Question 11

Drugs that induced cyp1A2

Answer 11

T3
Taxine
Theophylline
Tamoxifen

Question 12

Cyp,2B6

Answer 12

Be CM for 6 years
Cyclophosphamide
Methadone

Question 13

Cyp2C9 Inducer

Answer 13

Phenytoin
Warfarin