Antifungal Drugs

Question 1

Fungi infxns are iatrogenic T/F

Answer 1

True.

Question 2

Fungi infxns occurs in immunocompromised patients using Immunosuppressants T/F

Answer 2

True

Question 3

List the three basis of Antifungal classification

Answer 3

Mechanism/Site of action.
Chemical nature
Route of administration

Question 4

List all the sites of actions of Antifungal drugs with examples.

Answer 4

A) Cell wall inhibitor: Echinocandin

B) Cell membrane Inhibitors;

C) Inhibitors of Nucleic acid synthesis; Flucystosine

D) Disruption of mitotic spindle formation/mitosis: Griseofulvin

Question 5

List the three diff M/O of cell membrane Inhibitors

Answer 5

B) Cell membrane Inhibitors;
i) Increasing permeability: Polyene
ii) Inhibiting lanosterol and Ergosterol synthesis: Allylamine
iii) Inhibiting Ergosterol: Azole