Immune Response To Infection

Question 1

Th1
Cytokine,
primary target cells,
major immune reactions

Answer 1

IFN Y
Macrophage
Macrophage activation

Question 2

Th1
Host defence
Role in disease

Answer 2

Host Defence: Intracellular pathogen
Role in disease: auto-immunity, chronic inflammation

Question 3

Th2
Cytokine,
primary target cells,
major immune reactions

Answer 3

IL-4, IL-5, IL-13.
Eosinophils.
Eosinophil and mast cell activation, alternative macrophage activation

Question 4

Th2
Host defence
Role in disease

Answer 4

Helminths
Allergy

Question 5

Th17-
Cytokine,
primary target cells,
major immune reactions

Answer 5

IL-17, IL-22.
Neutrophils,
Neutrophil recruitment+activation

Question 6

Th17
Host defence
Role in disease

Answer 6

Extracellular bacteria and fungi.
Autoimmunity and inflammation.

Question 7

Defect: chronic granulomatous disease

Answer 7

Dysfunction/genes: loss of ROS production

Question 8

Defect: cytokine genes and their receptor

Answer 8

Genes: loss of cell-to-cell communication

Question 9

Defect: SCID

Answer 9

SCID= severe combined immunodeficiency
Gene: severe reduction and function of T+B cells

Question 10

Defects: HIV

Answer 10

Gene: reduced CD4 helper cells

Question 11

Defects: irradiation and chemotherapy (cancer treatment)

Answer 11

Gene: loss of bone-marrow precursors

Question 12

Defects: immuno suppression (graft rejection/chronic disease)

Answer 12

Dysfunction/gene: depletion/impairment of lymphocytes